Search results for: bioinorganic-chemistry

Bioinorganic Chemistry

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Principles of Bioinorganic Chemistry

Author : Stephen J. Lippard
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As one of the most dynamic fields in contemporary science, bioinorganic chemistry lies at a natural juncture between chemistry, biology, and medicine. This rapidly expanding field probes fascinating questions about the uses of metal ions in nature. Respiration, metabolism, photosynthesis, gene regulation, and nerve impulse transmission are a few of the many natural processes that require metal ions, and new systems are continually being discovered. The use of unnatural metals - which have been introduced into human biology as diagnostic probes and drugs - is another active area of tremendous medical significance. This introductory text, written by two pioneering researchers, is destined to become a landmark in the field of bioinorganic chemistry through its organized unification of key topics. Accessible to undergraduates, the book provides necessary background information on coordination chemistry, biochemistry, and physical methods before delving into topics that are central to the field: What metals are chosen and how are they taken up by cells? How are the concentrations of metals controlled and utilized in cells? How do metals bind to and fold biomolecules? What principles govern electron transfer and substrate binding and activation reactions? How do proteins fine-tune the properties of metals for specific functions? For each topic discussed, fundamentals are identified and then clarified through selected examples. An extraordinarily readable writing style combines with chapter-opening principles, study problems, and beautifully rendered two-color illustrations to make this book an ideal choice for instructors, students, and researchers in the chemical, biological, and medicalcommunities.

Bioinorganic Chemistry

Author : Ei-Ichiro Ochiai
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Written by a preeminent teacher and scientist in the field, this book provides specialists, students, and general readers with an understanding of the basic chemistry of interactions of inorganic substances with biological systems at the molecular level. The author presents bioinorganic concepts in context and brings a distinct chemistry perspective to the subject. • Provides the streamlined coverage appropriate for one-semester courses or independent study, with all of the necessary but none of the excessive information • Prepares readers to move to the next level of study (whether they continue on in the field or transition to medicine/industry) • Presents concepts through extensive four-color visuals, appealing to a range of learning styles • Promotes critical thinking through open-ended questions throughout the narrative and at the end of each chapter

Bioinorganic Chemistry

Author : K. Hussain Reddy
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The Coverage In This Book Is Organised In Terms Of The Syllabus Prescribed In Ugc Model Curriculum 2001 For Both Undergraduate And Postgraduate Students Of Chemistry And Biological Sciences.The Book Provides A Comprehensive And In-Depth Treatment Of The Subject. In Addition To Explaining The Basic Principles And Applications In Bioinorganic Chemistry, The Book Also Describes: * Photosynthesis. * Metal Complexes And Their Interaction With Nucleic Acids. * Effect Of Inorganic Pollutants On Biological Systems.The Book Would Serve As An Ideal Text For Students Of Chemistry And Biological Sciences. Researchers In Related Areas Would Find It An Extremely Useful Reference Source.

Bioinorganic Chemistry

Author : Rosette M. Roat-Malone
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An updated, practical guide to bioinorganic chemistry Bioinorganic Chemistry: A Short Course, Second Edition provides the fundamentals of inorganic chemistry and biochemistry relevant to understanding bioinorganic topics. Rather than striving to provide a broad overview of the whole, rapidly expanding field, this resource provides essential background material, followed by detailed information on selected topics. The goal is to give readers the background, tools, and skills to research and study bioinorganic topics of special interest to them. This extensively updated premier reference and text: Presents review chapters on the essentials of inorganic chemistry and biochemistry Includes up-to-date information on instrumental and analytical techniques and computer-aided modeling and visualization programs Familiarizes readers with the primary literature sources and online resources Includes detailed coverage of Group 1 and 2 metal ions, concentrating on biological molecules that feature sodium, potassium, magnesium, and calcium ions Describes proteins and enzymes with iron-containing porphyrin ligand systems-myoglobin, hemoglobin, and the ubiquitous cytochrome metalloenzymes-and the non-heme, iron-containing proteins aconitase and methane monooxygenase Appropriate for one-semester bioinorganic chemistry courses for chemistry, biochemistry, and biology majors, this text is ideal for upper-level undergraduate and beginning graduate students. It is also a valuable reference for practitioners and researchers who need a general introduction to bioinorganic chemistry, as well as chemists who want an accessible desk reference.

Bioinorganic Chemistry

Author : Nils Metzler-Nolte
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This book presents a unique introduction into the field of bioinorganic chemistry through practical laboratory experiments. Topics include many aspects of modern bioinorganic chemistry such as model systems for metalloenzymes, biosensors, metal bioconjugates and metal-based drugs. Each chapter contains a brief introduction, followed by detailed experimental procedures, completed with all necessary background information for the student as well as their instructors. A valuable supplement to standard textbooks of inorganic and bioinorganic chemistry Essential for all instructors teaching laboratory courses in general and inorganic chemistry

Element Speciation in Bioinorganic Chemistry

Author : Sergio Caroli
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Element speciation determines the different forms a chemicalelement can take within a given compound, enabling chemists topredict possible ramifications for the environment and humanhealth. This comprehensive book focuses on the analytical aspectsand instrumentation of speciation, while covering the gamut ofmetal speciation forms with adverse effects on biological materialsand the environment at large. The book consists of contributions by a truly international groupof leading authorities on element speciation in bioinorganicchemistry. The editor--a contributor here himself--traces thedevelopments in the field, discussing the advances made over thepast decade in various methodologies and the significance of theincreased capacity to detect extremely small concentrations oftrace elements in various media. Several chapters are dedicated to the various methods andapplications of speciation, exploring specific analytical methods,such as direct, chromatographic and nonchromatographic methods, aswell as nuclear-based and voltammetric methods. Others coverspeciation in various natural water and marine environments and itsmanifestation in biological materials, human serum, or foodstuff.In addition, the book examines speciation theory and legal aspectsas well as questions of quality and sources of errors--issues thatunderscore the perennial need to develop new methods for obtainingstill more accurate data. Extremely broad in scope and rich in detail, this volume providesthe key to improving the state of the art in the field, and is sureto stimulate further research. It stands as a one-of-a-kindreference for analytical and inorganic chemists, as well asbiochemists, in a wide range of disciplines, including toxicology,environmental science, nutrition research, clinical chemistry, andpharmacology. A complete reference for the analytical and instrumental aspects ofspeciation This unique volume provides both a comprehensive reference and apractical guide to the complete range of issues arising fromelement speciation. It concentrates on analytical methods andinstrumentation in bioinorganic chemistry--especially as applied towater-related projects--while addressing the larger environmentaland human-health concerns of our times. Complete with over 100 illustrations, this collaborative effort byan international group of experts describes * Methods for the detection and analysis of species elements,including direct methods, atomic spectrometry, nuclear activationanalysis and radio tracer, high-performance chromatography, orvoltammetric procedures * Specific effects of various species elements, including heavymetals, arsenic, and many other trace elements * Biological materials showing concentrations of trace elements,including human serum, milk, and marine organisms * Various environments affected by element speciation, such asnatural waters, sea waters, estuarine, and coastal environments * How to avoid common pitfalls and obtain sound and accuratedata For anyone involved in environmental and earth sciences, as well asthe related areas of public health, pharmacology, toxicology,nutritional research, or environmental regulations, this importantwork offers the most systematic survey of element speciation todate. It also provides historical perspective, a preview ofexpected developments, and a multitude of new ideas for furtherresearch. The author of approximately 240 published papers and three previousbooks, Dr. Caroli is an active member of numerous national andinternational committees and organizations concerned with chemicalsin the environment. He also sits on the editorial or advisoryboards of several scientific journals, including the Journal ofAnalytical Atomic Spectroscopy, Environmental Science and PollutionResearch International, and Microchemical Journal.

Current Research Topics in Bioinorganic Chemistry

Author : Stephen J. Lippard
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This comprehensive series of volumes on inorganic chemistry provides inorganic chemists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Every volume reports recent progress with a significant, up-to-date selection of papers by internationally recognized researchers, complemented by detailed discussions and complete documentation. Each volume features a complete subject index and the series includes a cumulative index as well.

Applications of Physical Methods to Inorganic and Bioinorganic Chemistry

Author : Robert A. Scott
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Modern spectroscopic and instrumental techniques are essential tothe practice of inorganic and bioinorganic chemistry. This firstvolume in the new Wiley Encyclopedia of Inorganic ChemistryMethods and Applications Series provides a consistent andcomprehensive description of the practical applicability of a largenumber of techniques to modern problems in inorganic andbioinorganic chemistry. The outcome is a text that providesinvaluable guidance and advice for inorganic and bioinorganicchemists to select appropriate techniques, whilst acting as asource to the understanding of these methods. This volume is also available as part of Encyclopedia ofInorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007to 2010, representing areas of key developments in the field ofinorganic chemistry published in the Encyclopedia of InorganicChemistry. ahref="http://eu.wiley.com/WileyCDA/WileyTitle/productCd-1119994284.html"Findout more/a.

The Bioinorganic Chemistry of Chromium

Author : John Vincent
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Chromium exists in nature as complexes of two stable oxidation states – trivalent chromium(III) and hexavalent chromium(VI). Although trivalent chromium is required in trace amounts for sugar and lipid metabolism in humans and its deficiency may cause a disease called chromium deficiency; hexavalent chromium is toxic and carcinogenic. As chromium compounds were used in dyes and paints and the tanning of leather, these compounds are often found in soil and groundwater at abandoned industrial sites, now needing environmental cleanup and remediation. The Bioinorganic Chemistry of Chromium: From Biochemistry to Environmental Toxicology takes a critical look at what the biochemical data indicate about chromium's role in the body and the biological mechanisms of its toxicology. Topics covered include: What do we know about the biochemical roles and mechanisms of chromium? Is chromium an essential element in the mammalian diet? Is chromium(III) effective as a nutraceutical, a therapeutic agent, and as a supplement in animal feed? What is the biochemistry behind the toxicology of chromium(III) and chromium(VI):the mechanisms of metabolism, genetic and epigenetic effects, and disruption of cell signalling? What are the current chromium(VI) policies and positions from regulatory agencies? The Bioinorganic Chemistry of Chromium: From Biochemistry to Environmental Toxicology is an important contribution to the bioinorganic and trace element biochemical fields which will find a place on the bookshelves of bioinorganic chemists, biochemists, inorganic chemists, toxicologists, nutritionists and regulatory affairs professionals.

Bioinorganic Chemistry Inorganic Elements in the Chemistry of Life

Author : Wolfgang Kaim
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The field of Bioinorganic Chemistry has grown significantly inrecent years; now one of the major sub-disciplines of InorganicChemistry, it has also pervaded other areas of the life sciencesdue to its highly interdisciplinary nature. Bioinorganic Chemistry: Inorganic Elements in the Chemistryof Life, Second Edition provides a detailed introduction to therole of inorganic elements in biology, taking a systematicelement-by-element approach to the topic. The second edition ofthis classic text has been fully revised and updated to include newstructure information, emerging developments in the field, and anincreased focus on medical applications of inorganic compounds. Newtopics have been added including materials aspects of bioinorganicchemistry, elemental cycles, bioorganometallic chemistry, medicalimaging and therapeutic advances. Topics covered include: Metals at the center of photosynthesis Uptake, transport, and storage of essential elements Catalysis through hemoproteins Biological functions of molybdenum, tungsten, vanadium andchromium Function and transport of alkaline and alkaline earth metalcations Biomineralization Biological functions of the non-metallic inorganicelements Bioinorganic chemistry of toxic metals Biochemical behavior of radionuclides and medical imaging usinginorganic compounds Chemotherapy involving non-essential elements This full color text provides a concise and comprehensive review ofbioinorganic chemistry for advanced students of chemistry,biochemistry, biology, medicine and environmental science.

Computational Inorganic and Bioinorganic Chemistry

Author : Edward I. Solomon
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Over the past several decades there have been major advances in our ability to computationally evaluate the electronic structure of inorganic molecules, particularly transition metal systems. This advancement is due to the Moore’s Law increase in computing power as well as the impact of density functional theory (DFT) and its implementation in commercial and freeware programs for quantum chemical calculations. Improved pure and hybrid density functionals are allowing DFT calculations with accuracy comparable to high-level Hartree-Fock treatments, and the results of these calculations can now be evaluated by experiment. When calculations are correlated to, and supported by, experimental data they can provide fundamental insight into electronic structure and its contributions to physical properties and chemical reactivity. This interplay continues to expand and contributes to both improved value of experimental results and improved accuracy of computational predictions. The purpose of this EIC Book is to provide state-of-the-art presentations of quantum mechanical and related methods and their applications, written by many of the leaders in the field. Part 1 of this volume focuses on methods, their background and implementation, and their use in describing bonding properties, energies, transition states and spectroscopic features. Part 2 focuses on applications in bioinorganic chemistry and Part 3 discusses inorganic chemistry, where electronic structure calculations have already had a major impact. This addition to the EIC Book series is of significant value to both experimentalists and theoreticians, and we anticipate that it will stimulate both further development of the methodology and its applications in the many interdisciplinary fields that comprise modern inorganic and bioinorganic chemistry. This volume is also available as part of Encyclopedia of Inorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007 to 2010, representing areas of key developments in the field of inorganic chemistry published in the Encyclopedia of Inorganic Chemistry. Find out more.

Biological Inorganic Chemistry

Author : Robert R. Crichton
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Biological Inorganic Chemistry: A New Introduction to Molecular Structure and Function, Second Edition, provides a comprehensive discussion of the biochemical aspects of metals in living systems. Beginning with an overview of metals and selected nonmetals in biology, the book then discusses the following concepts: basic coordination chemistry for biologists; structural and molecular biology for chemists; biological ligands for metal ions; intermediary metabolism and bioenergetics; and methods to study metals in biological systems. The book also covers metal assimilation pathways; transport, storage, and homeostasis of metal ions; sodium and potassium channels and pumps; magnesium phosphate metabolism and photoreceptors; calcium and cellular signaling; the catalytic role of several classes of mononuclear zinc enzymes; the biological chemistry of iron; and copper chemistry and biochemistry. In addition, the book discusses nickel and cobalt enzymes; manganese chemistry and biochemistry; molybdenum, tungsten, vanadium, and chromium; non-metals in biology; biomineralization; metals in the brain; metals and neurodegeneration; metals in medicine and metals as drugs; and metals in the environment. Winner of a 2013 Textbook Excellence Awards (Texty) from the Text and Academic Authors Association Readable style, complemented by anecdotes and footnotes Enables the reader to more readily grasp the biological and clinical relevance of the subject Color illustrations enable easy visualization of molecular mechanisms

Practical Approaches to Biological Inorganic Chemistry

Author : Robert R. Crichton
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The book reviews the use of spectroscopic and related methods to investigate the complex structures and mechanisms of biological inorganic systems that contain metals. Each chapter presents an overview of the technique including relevant theory, clearly explains what it is and how it works and then presents how the technique is actually used to evaluate biological structures. Practical examples and problems are included to illustrate each technique and to aid understanding. Designed for students and researchers who want to learn both the basics, and more advanced aspects of bioinorganic chemistry. Many colour illustrations enable easier visualization of molecular mechanisms and structures Worked examples and problems are included to illustrate and test the reader’s understanding of each technique Written by a multi-author team who use and teach the most important techniques used today to analyse complex biological structures

Biological Inorganic Chemistry

Author : Gray Bertini
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Part A.: Overviews of biological inorganic chemistry : 1. Bioinorganic chemistry and the biogeochemical cycles -- 2. Metal ions and proteins: binding, stability, and folding -- 3. Special cofactors and metal clusters -- 4. Transport and storage of metal ions in biology -- 5. Biominerals and biomineralization -- 6. Metals in medicine. -- Part B.: Metal ion containing biological systems : 1. Metal ion transport and storage -- 2. Hydrolytic chemistry -- 3. Electron transfer, respiration, and photosynthesis -- 4. Oxygen metabolism -- 5. Hydrogen, carbon, and sulfur metabolism -- 6. Metalloenzymes with radical intermediates -- 7. Metal ion receptors and signaling. -- Cell biology, biochemistry, and evolution: Tutorial I. -- Fundamentals of coordination chemistry: Tutorial II.

Bioinorganic Chemistry

Author : Eric C. Long
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This book emphasizes current cutting edge research topics in two areas of modern bioinorganic chemistry: the role of metals in cellular systems involving multiple biomacromolecular components and sophisticated new model systems involving peptide- and non-peptide-based ligands.

Bioinorganic Chemistry

Author : Ivano Bertini
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Written by major contributors to the field, Bioinorganic Chemistry provides students with an introduction and overview of the subject and gives them the background required to read and follow the current research literature.

Bioinorganic Chemistry

Author : Alfred X. Trautwein
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Whenever nature has a difficult task to perform it can be expected that a metal ion or a cluster of such ions is employed. Metal ions are indispensable for the integrity of biological structures and the catalysis of biological reactions. Knowledge about their mode of action, their uptake in the cell, their handling and their storage is important for the development of new pharmaceuticals. This book summarizes latest results of interdisciplinary research on several universities.

Bioinorganic Chemistry

Author : R. J. Williams
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In this book the first three chapters outline the chemistry of nickel and heme largely associated with anaerobic life and believed to represent reactions which took place some 3-4x109years ago. Nickel has disappeared from the chemistry of man. The fascinating detail of the "primitive" catalysts is of interest to industrial society since very simple feed-stock is used, hydrogen, carbon monoxide and sulphate for example. The fourth chapter switches attention to a metal which became valuable later in evolution, copper, and which is involved with the use of dioxygen. It also has extremely interesting catalytic sites in enzymes. The essence of the volume lies in an appreciation of metallo- enzymes and their changing roles as the environment changed.

Mechanistic Bioinorganic Chemistry

Author : American Chemical Society. Meeting
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Provides an understanding of bioinorganic reactions from a mechanistic point of view. Illustrates how spectroscopy can be used to establish mechanisms and how model compounds provide mechanistic insight for enzymes. Demonstrates how to apply numerous physical methods to understanding mechanisms of redox catalysis by metal centers in enzymes. Highlights the interrelationships between the roles of metal ions in electron transfer, redox catalysis, structural roles, and hydrolytic chemistry. Provides mechanistic insights into water oxidation, nitrogen fixation, nucleic acid oxidation and hydrolysis, oxygen binding, catalase reactions, and electron transfer.