Search results for: cellular-degradative-processes

Cellular Degradative Processes

Author : R. T. Dean
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Degradative Processes in Heart and Skeletal Muscle

Author : Kern Wildenthal
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Molecular Basis of Biological Degradative processes

Author : Richard Berlin
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Molecular Basis of Biological Degradative Processes contains the proceedings of the 1977 symposium held at the University of Connecticut Health Science Center. The papers focus on the molecular mechanisms underlying the biological degradation, including the relationship between the lysosome and tissue remodeling and the role of this organelle in processing intra- and extracellular material. The book also explores the specific application of the lysosome concept to the description of deficiency diseases of lipid catabolism. Organized into 12 chapters, this book begins with an overview of the mechanisms underlying cell death and its control, along with possible experimental models for its study, nutrient deficiencies during prenatal development, and congenital diseases resulting from zinc, magnesium, and manganese deficiencies. It explains the clinical lysosome deficiencies, the early phase of blood coagulation, cascade events in the activation and function of mast cells, activation of plasminogen and its involvement in the production of localized extracellular proteolysis, and proteolytic events in viral replication. Chapters on human neutrophil elastase and the protease-pathogenesis model of pulmonary emphysema; dissolution mechanism of apatite crystals during dental caries and bone resorption; and degradative processes of bone follow. This book is a valuable resource for biologists, physiologists, and those involved in basic and applied research in ""catabolic"" processes.

Quantification of Cognitive Process Degradation While Mobile Attributable to the Environmental Stressors Endurance Vibration and Noise

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Operator cognitive performance was quantified in an off-road environment by repeatedly administering a battery of cognitive measures to assess the genus and degree of performance while mobile. Environmental stressors referred to as endurance, tracked vehicle vibration per intensity, and noise were recorded over the course of one day per participant (n=18). Vibration conditions presented were varying amplitudes approximating accelerations of 0.88 g by a frequency of 3 cycles per second (cps), 0.65 g by 4 cps, and 0.03 g by 12.5 cps. Observed collectively, the predictor variables returned a multiple R value for the dependent variable percent correct of 0.733 (p

Protein Degradation

Author : R. John Mayer
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The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Protein Degradation

Author : R. John Mayer
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Annotation. The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Molecular Biology of the Cell

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Issues in Proteins and Peptides Research and Application 2012 Edition

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Issues in Proteins and Peptides Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Protein Science. The editors have built Issues in Proteins and Peptides Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Science in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Proteins and Peptides Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Protein Degradation

Author : R. John Mayer
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The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Protein Degradation

Author : R. John Mayer
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The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Current Topics in Cellular Regulation

Author : Bernard L. Horecker
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Current Topics in Cellular Regulation, Volume 21 examines the advances in the general area of cellular regulation. This book discusses the roles of eukaryotic initiation factor 2 ancillary factors in the regulation of eukaryotic protein synthesis initiation and phosphorylation state of eIF-2. The monoclonal antibodies to cap-binding proteins, criteria for establishment of the biological significance of ribosomal protein phosphorylation, and comparison with casein kinases from mammary gland are also elaborated. This text likewise covers the regulation of phosphoprotein phosphatases, poly(ADP-ribosyl)ation reactions in vitro, and induced commitment to terminal erythroid differentiation. Other topics include the turnover characteristics of lactate dehydrogenase and role of urea synthesis in the removal of metabolic bicarbonate and regulation of blood pH. This volume is useful to biologists and researchers interested in basic mechanisms involved in the regulation of diverse cellular activities.

Ubiquitin dependent Protein Degradation

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Ubiquitination and Protein Stability - Part B, Volume 619, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this updated volume presenting interesting chapters written by an international board of authors. Topics of note include chapters on Assays of SUMO protease function in mammalian cells, In vitro analysis of proteasome-associated USP14 activity for substrate degradation and deubiquitylation, Methods to study proteasome regulatory particle assembly, Native mass spectrometry approaches to study the proteasome, Single-molecule methods to study the ubiquitin-proteasome system, Assays for the function of ubiquitin in the mammalian endocytic pathway, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in this series on enzymology

Phosphoinositides I Enzymes of Synthesis and Degradation

Author : Tamas Balla
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Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Hormones in Human Plasma

Author : Harry N. Antoniades
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Protein Degradation

Author : R. John Mayer
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The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Cartilage Degradation and Repair

Author : C. Andrew L. Bassett
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The Receptors

Author : P. Michael Conn
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The Receptors, Volume II deals with receptors for somatostatin, vitamin D, insulin, and animal viruses, as well as for the ?2-adrenergic and Ah systems. The significance of translational modifications of receptor ligands is discussed, along with the mechanisms of receptor-ligand interactions. The role of receptors in development and their regulation by tumors are also considered. Comprised of 12 chapters, this volume begins with a detailed account of the vitamin D receptor, paying particular attention to its biochemical and physical properties as well as its mechanism of action. The discussion then turns to experimental discrimination between alternative mechanistic models for the receptor-mediated stimulation of adenylate cyclase; the role of microaggregation in hormone-receptor-effector interactions; and the biology and biochemistry of the Ah receptor. Subsequent chapters explore the interactions of animal viruses with cell surface receptors; insulin receptors; determination of the size of neurotransmitter receptors by radiation inactivation-target size analysis; and protein glycosylation and receptor-ligand interactions. This book will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

The spatiotemporal dynamics of longevity defining cellular processes and its modulation by genetic dietary and pharmacological anti aging interventions

Author : Vladimir I. Titorenko
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Aging of multicellular and unicellular eukaryotic organisms is a highly complex biological phenomenon that affects a plethora of processes within cells. This wide array of longevity-defining cellular processes - which are governed by an evolutionarily conserved signaling network - includes oxidative metabolism and protein synthesis in mitochondria, lipid and carbohydrate metabolism, NAD+ homeostasis, amino acid biosynthesis and degradation, ammonium and amino acid uptake, ribosome biogenesis and translation, proteasomal protein degradation, nuclear DNA replication, chromatin assembly and maintenance, actin organization, apoptosis, necrosis, autophagy, protein folding, stress response, signal transduction, cell cycle, and cell growth. The focus of this Frontiers Special Topic Issue is on an important conceptual advance in our understanding of how cells integrate and control these numerous processes and how genetic, dietary and pharmacological anti-aging interventions extend longevity by altering their functional states and spatiotemporal dynamics. The Issue will highlight the various strategies used by evolutionarily diverse organisms for coordinating these longevity-defining cellular processes in space and time, critically evaluate the molecular and cellular mechanisms underlying such coordination, and outline the most important unanswered questions and directions for future research in this vibrant and rapidly evolving field.

Host Directed Therapies for Tuberculosis

Author : Vishwanath Venketaraman
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TB is considered as one of the oldest documented infectious diseases in the world and is believed to be the leading cause of mortality due to a single infectious agent. Mtb, the causative agent responsible for TB, continues to afflict millions of people worldwide. Furthermore, one-third of the entire world's population has latent TB. Consequently, there has been a worldwide effort to eradicate and limit the spread of Mtb through the use of antibiotics. However, management of TB is becoming more challenging with the emergence of drug-resistant and multi-drug resistant strains of Mtb. Furthermore, when administered, many of the anti-TB drugs commonly present severe complications and side effects. Novel approaches to enhance the host immune responses to completely eradicate Mtb infection are urgently needed. This Special Issue will therefore cover most recent advances in the area of host-directed therapies for TB.

Biological Degradation of Lignin Part I

Author : John Frank Kratochvil
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