Search results for: connectomic-deep-brain-stimulation

Connectomic Deep Brain Stimulation

Author : Andreas Horn
File Size : 86.35 MB
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Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) Presents references (key articles, books and protocols) for additional detailed study Provides data analysis boxes in each chapter to help with data interpretation

Toward Connectomic Deep Brain Stimulation

Author : Andreas Horn
File Size : 51.97 MB
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Reliability and Reproducibility in Functional Connectomics

Author : Xi-Nian Zuo
File Size : 60.23 MB
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Functional connectomics enables researchers to monitor interactions among thousands of units within the whole brain simultaneously by using various vivo imaging technologies. For example, resting-state functional magnetic resonance imaging can image low-frequency fluctuations in the spontaneous brain activities, representing a popular tool for macro-scale functional connectomics to characterize individual differences in normal brain function, mind-brain associations, and the various disorders. Reliability and reproducibility represents the most fundamental and critical aspect for the human brain functional connectomics to both research and clinical practice. Unfortunately, lacking a data platform for researchers to rigorously explore the reliability and reproducibility of the functional connectome indices has been a bottleneck of further development of clinically oriented imaging markers in the field. Recent efforts on open neuroscience, such as Consortium for Reliability and Reproducibility, Human Connectome Project and OpenFMRI, provide the data for the field to refine and evaluate reliability and reproducibility of novel methods as well as those with widespread usage but without sufficient consideration of reliability. This Frontiers Research Topic aims at bringing together contributions from researchers in brain imaging, neuroscience, computer sciences, applied mathematics, psychology and related fields from an interdisciplinary perspective. By focusing on cutting-edge research across these fields, this topic will create new agenda on quantifying the reliability and reproducibility of the myriad connectomics-based measures and informing expectations regarding the potential of biomarker discovery.

Deep Brain Stimulation Think Tank Updates in Neurotechnology and Neuromodulation Research

Author : Michael S. Okun
File Size : 58.31 MB
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Translational Side of Emerging Invasive and Non Invasive Stimulation Therapies

Author : Jiande Chen
File Size : 32.83 MB
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Towards the Next Generation of Deep Brain Stimulation Therapies Technological Advancements Computational Methods and New Targets

Author : George C. McConnell
File Size : 58.17 MB
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Author : Madhukar H. Trivedi
File Size : 74.4 MB
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Major depressive disorder (MDD) is a serious, debilitating, life-shortening illness that affects many persons of all ages and backgrounds. The lifetime risk for MDD is 7-12% for men and 20-25% for women (Kessler et al., 2003). MDD is a disabling disorder that costs the U.S. over $200 billionper year in direct and indirect costs (Greenberg et al., 2015), and is the leading cause of disability worldwide (WHO, 2018). Depression also has detrimental effects on all aspects of social functioning (e.g., self-care, social role, and family life, including household, marital, kinship, andparental roles). While there have been several treatments that are efficacious, many individuals suffering from depression experience life-long challenges due to the chronic and episodic nature of the disease. Identifying strategies to find the right treatments for the right patients is critical.Ongoing research has explored the importance of examining physiologic biomarkers, as well as clinical characteristics to gain a better understanding of subtypes of depression, which will lead to improved treatments and better outcomes.This book provides an introduction to the etiology and pathophysiology of depression, common comorbidities and differential diagnoses, pharmacotherapy strategies, psychotherapeutic and neuromodulation interventions, novel and non-traditional treatment strategies, and considerations in specialpopulations.

Trends in Clinical Deep Brain Stimulation

Author : Marcus L. F. Janssen
File Size : 79.19 MB
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This book covers the current trends in clinical deep brain stimulation (DBS) research. This collection of papers from experts in the field provides state of the art knowledge and future perspectives in clinical DBS research. A range of topics involved in DBS is presented, ranging from high resolution imaging, electrophysiology and personalized medicine, in a broad range of brain disorders.

Deep Brain Stimulation Management

Author : William J. Marks
File Size : 72.61 MB
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"In teaching clinicians around the world about the various facets of DBS for many years, we have found there to be a need for a concise but comprehensive practical guide for clinicians interested in becoming involved with, or who are already involved in, using DBS for their patients. Thus, this book was created to serve as a practical reference - a "go to" guide to be kept in the clinic and consulted in the course of managing patients being considered for or treated with DBS. We designed this book to address in a clear, comprehensive, and yet concise manner all of the key topics pertaining to use of DBS for clinicians. The First Edition of this book focused on the use of DBS to treat movement disorders and was extremely well received in the United States and internationally. The Second Edition provided updates and added dedicated chapters on the treatment of epilepsy and psychiatric disorders with DBS, as well as a new chapter focused on interventional MRI approaches to DBS lead implantation. In this new Third Edition, we've updated the content, included the latest information on new DBS devices, and expanded information on a broader scope of conditions that may benefit from treatment with DBS. We begin with a practical discussion of how to implement a DBS program. We then turn to surgical aspects, including new approaches to DBS lead implantation. Following this, we outline the neurophysiological principles of DBS, discuss the clinical aspects of DBS generally and for specific movement disorders, and then turn to the emerging indications of epilepsy, psychiatric conditions, and other disorders. Finally, we end with a comprehensive discussion of troubleshooting"--

Fundamentals and Clinics of Deep Brain Stimulation

Author : Yasin Temel
File Size : 57.98 MB
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This book provides a state-of-the-art overview of our current understanding of deep brain stimulation (DBS) for the treatment of neurological and psychiatric disorders. With a broad multidisciplinary scope, it presents contributions from leading experts in the field from Europe and America, who share not only their knowledge, but their experience as well. The book focuses both on basic and theoretical aspects of DBS, as well as clinical and practical aspects. It follows an evidence-based approach, and where possible offers clinical recommendations based on published guidelines. It starts with a general section, which discusses basic principles and general considerations. This is followed a sections dedicated to neurological disorders, and psychiatric disorders, in which only accepted indications are discussed. All experimental indications are discussed in the final chapter. The text is supplemented with numerous illustrations. Intended for medical specialists and residents involved in the treatment of patients with DBS, it also appeals to other professionals working with DBS patients, such as psychologists, nurses, physiotherapists, as well as basic and clinical neuroscientists.