Search results for: enzymes-of-the-cholinesterase-family

Enzymes of the Cholinesterase Family

Author : A.S. Balasubramanian
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The Fifth International Meeting on Cholinesterases convened in Madras, India, in September of 1994. The long and rich history and culture of India provided an excellent setting for the meeting. More than 120 delegates from Asia, Australia, Europe and North America heard 54 oral presentations and viewed 54 posters on current research on enzymes of the cholinesterase family. The aim of this book is to compile the presentations of the Fifth International Meeting on Cholinesterases into a volume that describes recent investigations on the structure and catalytic function of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and related enzymes, as well as studies on the molecular and cellular biology of these enzymes and the genes which encode them. Cholinesterases enjoy a long and storied history in diverse areas. In basic biochemical research, AChE is one of the best studied, though yet enigmatic, of enzymes. The efficient catalytic function of this enzyme presents the biochemist with a fundamental challenge in understanding the relationship between structure and function. AChE and BuChE belong to a family of proteins, the alB hydrolase fold family, whose constituents evolutionarily diverged from a common ancestor. Proteins in this family have a wide range of physiological functions. In commerce, AChE is a prime target for agricultural insect control, and for the development of therapeutic agents for Alzheimer's disease.

Comparative Enzymology of Cholinesterases

Author : Serge N. Moralev
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Neurotransmitters in Plants

Author : Akula Ramakrishna
File Size : 76.62 MB
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New scientific data confirm the origin of neurotransmitters in the ancient ocean, whose inhabitants use the compounds in their relationships. One example is the algae Ulvaria, whose image is represented on the cover. During evolution, plant and microbial cells stored the neurotransmitters that play multifunctional roles today. Researchers have paid special attention to their functions in plants, the oxygen well of our planet. This book provides powerful tools for both analyzing and manipulating organisms, considering the functions of neurotransmitters in plant cells and the practical application of knowledge about acetylcholine, catecholamines, serotonin, melatonin, histamine, gamma-aminobutyric acid and glutamine for ecology, agriculture, medicine and food industries. Neurotransmitters in Plants: Perspectives and Applications presents information on: the location and biosynthesis where neurotransmitters occur the molecular biology of some enzymes participating in the process their role in vivo and in vitro processes their functions in plant environmental adaptation in plants their role in enriching the food and medicinal value of plants.

Comprehensive Toxicology Volume 3

Author : F.P. Guengerich
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This volume deals with the enzymatic processes involved in the biotransformation of toxic and potentially toxic chemicals. The first section provides introductory material on general aspects of history, regulation, mechanism, inhibition, and stimulation of the enzymes in this group. The bulk of the volume is comprised of chapters dealing with the current status of enzymes involved in oxidation, reduction, hydrolysis, and conjugation of xenobiotic chemicals. Each chapter is organized to cover the current status of enzyme multiplicity and nomenclature, gene and protein structure, regulation, catalytic mechanism, substrate specificity, human studies, and relevance to issues in toxicology.

Cholinergic Mechanisms

Author : Israel Silman
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Providing a cutting-edge profile of research progress in this important field of study, Cholinergic Mechanisms: Function and Dysfunction contains a compilation of the proceedings of the Eleventh ISCM, held in St. Moritz, May 2002. Bringing together 250 contributors from 30 countries, the book presents a comprehensive picture of the cholinergic field. It provides a survey of current understanding of molecular, pharmacological, toxicological, behavioral, and clinical aspects of the cholinergic system. This volume offers a state-of-the-art account of progress in the field from the molecule in the test tube through the cell and the synapse, to the organism and the patient.

Toxicology of Organophosphate and Carbamate Compounds

Author : Ramesh C. Gupta
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This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides. Describes everything you need to know about Organophosphates and Carbamates Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis Provides in vitro and in vivo models for neurotoxicity testing Integrates knowledge of studies in lab animals and humans Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues Describes management of Anticholinesterase poisoning in humans

Alzheimer Disease

Author : Robert Becker
File Size : 54.63 MB
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Biosensors for Direct Monitoring of Environmental Pollutants in Field

Author : D.P. Nikolelis
File Size : 31.47 MB
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Biosensors offer clear and distinct advantages over standard analytical methods for the direct monitoring of environmental pollutants in the field, such as real-time detection with minimum sample preparation and handling. The present book highlights recent advantages that will be of great value to a range of scientists, researchers and students dealing with analytical and environmental chemistry and biosensor technology. It presents recent trends in analytical methodology for the determination of indoor and outdoor pollutants, advances in DNA, biological and recognition-based sensors, examples of biosensors for use in field and water analysis, biosensors based on non-aqueous systems, and recent advances in the miniaturisation and micromachining of biosensors.

Simulations of Molecules and Processes in the Synapse

Author : Kaihsu Tai
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Structural and Kinetic Characterization of Cholinesterases

Author : Natilie A. Hosea
File Size : 47.83 MB
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Nurse Anesthesia E Book

Author : John J. Nagelhout
File Size : 75.87 MB
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Long respected as the most comprehensive nurse anesthesia resource available, this new edition continues the tradition of bringing together leading experts to create a balanced reference that applies scientific principles to today’s clinical anesthesia practice. Inside you’ll find a solid introduction to the equipment and patient care techniques unique to nurse anesthesia side-by-side with the cutting-edge research and application of evidence necessary to prepare you for tomorrow. Over 700 tables and boxes highlight the most essential information in a quick, easy-to-reference format. An easy-to-use organization with basic principles covered first, followed by individual chapters for each surgical specialty, ensures you have the information you need to build your knowledge. Over 650 figures of anatomy, nurse anesthesia procedures, and equipment enhance your understanding of complex information. Expert CRNA authors provide the most up-to-date and relevant clinical information you’ll use in daily practice. The latest pharmacology information on pharmacokinetics, drug delivery systems, opiate antagonists, and key induction drugs to keep you up-to-date. Thoroughly updated references make finding the latest and most important research in the field quick and simple. New chapters address legal issues, neonatal anesthesia, anesthesia education, clinical monitoring, regional anesthesia, unexpected complications, and more. Expanded coverage of chemistry and physics as well as immunology makes these difficult fundamental topics easier to understand and apply to everyday practice. Over 100 new images enhance your understanding of difficult anesthesia concepts.

Recent Trends in the Acetylcholinesterase System

Author : Mahira Parveen
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The enzyme acetylcholinesterase (AChE) has drawn the attention of scientist as it has played a striking role in Alzheimers disease, Cardiac diseases and other diseases. A good discussion and overview document on AChE enzyme and its various aspects was felt lacking since long time in the field of enzyme Biochemistry as well as enzyme Biotechnology and this publication fills this gap. Before this publication there was no data available in AChE enzyme inhibition, its kinetics, its peripheral sites, their role in catalytic and noncholinergic function of enzyme, Ach receptors, AChE and BuChE genes etc. All these topics together form a good basis for researchers and post graduate students in this field of interest. This book is exclusively based on recent works reported in the field of AChE enzyme and is a collection volume of recent advanced reports and data on AChE Enzyme.

Chemical Warfare Agents Toxicology and Treatment

Author : Dr Timothy T. Marrs
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Chemical Warfare Agents, Second Edition has been totally revised since the successful first edition and expanded to about three times the length, with many new chapters and much more in-depth consideration of all the topics. The chapters have been written by distinguished international experts in various aspects of chemical warfare agents and edited by an experienced team to produce a clear review of the field. The book now contains a wealth of material on the mechanisms of action of the major chemical warfare agents, including the nerve agent cyclosarin, formally considered to be of secondary importance, as well as ricin and abrin. Chemical Warfare Agents, Second Edition discusses the physico-chemical properties of chemical warfare agents, their dispersion and fate in the environment, their toxicology and management of their effects on humans, decontamination and protective equipment. New chapters cover the experience gained after the use of sarin to attack travellers on the Tokyo subway and how to deal with the outcome of the deployment of riot control agents such as CS gas. This book provides a comprehensive review of chemical warfare agents, assessing all available evidence regarding the medical, technical and legal aspects of their use. It is an invaluable reference work for physicians, public health planners, regulators and any other professionals involved in this field. Review of the First Edition: "What more appropriate time for a title of this scope than in the post 9/11 era? ...a timely, scholarly, and well-written volume which offers much information of immense current and…future benefit." —VETERINARY AND HUMAN TOXICOLOGY

Human Cholinesterases and Anticholinesterases

Author : Hermona Soreq
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Human Cholinesterases and Anticholinesterases summarizes the many fundamental concepts of human cholinesterases (ChEs) and their inhibitors. This book is divided into three chapters that represent human cholinesterase research studies from different points of view. Chapter 1 deals with the biochemical and biological background of human ChEs. This chapter also examines the molecular polymorphism, genomic origin, genetic variants, and biological roles of these enzymes. Chapter 2 provides the molecular characterization of human ChE genes and their multileveled regulation, with a special emphasis on butyrylcholinesterase. Chapter 3 discusses the scientific, ecological, and clinical implications of the studies presented in the previous chapters. Protein scientists, engineers, and researchers will find this work invaluable.

Pharmacology and Physiology for Anesthesia E Book

Author : Hugh C. Hemmings
File Size : 26.58 MB
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Better understand the complexities of pharmacology and physiology relevant to your practice with the brand-new medical reference book, Pharmacology and Physiology for Anesthesia. Drs. Hugh Hemmings and Talmage Egan provide the clinical insights you need to effectively administer anesthesia, ensuring patient safety and the most optimal outcomes. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Access comprehensive, continually updated research on the physiology of organ systems and clinical topics in the pharmacology of anesthetic drugs. Quickly and easily reference the information you need through user-friendly tables, figures, and algorithms, all presented in lavish full color throughout. Understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these key areas.

Mendelian Inheritance in Man

Author : Victor Almon McKusick
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A classic bibliographic guide to human genetics, first published in book form in 1966. Each entry consists of six parts: a preferred designation, followed in parentheses by frequently used synonyms; a brief description of the phenotype(s); the nature of the basic defect; a resume of genetic information, including mapping and molecular genetic details; allelic variants; and key references. This edition contains 36,987 references, mainly to the periodical literature, and cites 54,623 authors. Based on a continuously updated online version, only four months separate closure of the file for the edition and the finished book. Annotation copyrighted by Book News, Inc., Portland, OR

Structure and Function of Cholinesterases and Related Proteins

Author : Bhupendra P. Doctor
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Proceedings of the Sixth International Meeting on Cholinesterases held in La Jolla, CA, March 20-24, 1998

Mosby s Diagnostic and Laboratory Test Reference eBook

Author : Kathleen Deska Pagana
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Access the clinically relevant information you need easily in any setting with Mosby's Diagnostic and Laboratory Test Reference, 10th Edition. This bestselling handbook provides concise coverage of tests without sacrificing important details. Each test entry includes, where relevant, alternate or abbreviated test names; type of test; normal findings; possible critical values; test explanation and related physiology; contraindications; potential complications; interfering factors; procedure and patient care (before, during, and after); and abnormal findings. Related tests are extensively cross-referenced throughout the book. With its simple format and portable size, this is a handy reference you'll always want by your side. Tests are organized alphabetically with A-to-Z thumb tabs for quick reference. UNIQUE! Each test entry begins on a new page, making tests easy to find. Normal findings for adult (male and female), elderly, and pediatric patients are included where applicable to provide complete clinical data. Possible critical values are highlighted to alert you to situations requiring immediate intervention. Symbol next to drug-related interfering factors alerts you to the effects of pharmacologic agents on tests. Increased and decreased abnormal findings are highlighted with directional arrows. Icon for patient teaching-related care indicates information to share with patients and their families. UNIQUE! Each test concludes with a Notes section where you can add your own information. User's Guide to Test Preparation and Performance provides an overview and guidelines for each type of laboratory test and diagnostic procedure to ensure safety and accuracy. Lists of tests by body system and test type allow you to quickly locate related studies. Abbreviations for tests are listed inside the front and back covers, and symbols and units of measurement are listed in an appendix. UNIQUE! Durable cover with round edges helps prevent the book from being damaged and makes it easier to handle. ~ 32 NEW tests, including age-related macular degeneration risk analysis, cell culture drug resistance testing, flourescein angiography, HIV drug resistance testing, urea breath test, virus testing, and Vitamin D testing, present the latest information on diagnostic and laboratory testing.

Mosby s Diagnostic and Laboratory Test Reference E Book

Author : Kathleen Deska Pagana
File Size : 37.57 MB
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Get fast access to important diagnostic tests and procedures with Mosby’s Diagnostic & Laboratory Test Reference, 12th Edition by Kathleen Deska Pagana, Timothy J. Pagana, and Theresa N. Pagana. In this bestselling handbook, concise test entries are arranged alphabetically and reflect the latest in research and diagnostic testing. Each test entry includes vital information such as type of test, alternate or abbreviated test names, test explanation, normal and abnormal findings, possible critical values, contraindications, potential complications, interfering factors, and patient care. To simplify lookup, related tests are cross-referenced. A compact size, durable cover, and A-to-Z thumb tabs make this book ideal for quick reference on the job. Alphabetically organized tests offer quick reference with A-to-Z thumb tabs, so you’ll never have to search for a test by having to first determine its correct category or body system. UNIQUE! Each test entry begins on a new page, making tests easy to find. User’s Guide to Test Preparation and Performance provides an overview and guidelines for each type of laboratory test and diagnostic procedure, so you can minimize worry about having to repeat a test due to an error. Normal findings for adult (male and female), elderly, and pediatric patients are included where applicable. Increased and decreased abnormal findings are highlighted with directional arrows. Possible critical values are highlighted to alert you to situations requiring immediate intervention. Patient care sections provide step-by-step instructions for care before, during, and after the test. Symbol next to drug-related interfering factors alerts you to the effects of pharmacologic agents on tests. Lists of tests by body system and test type make it easy to cross-reference related studies. Abbreviations for tests are listed in the front and the back of the book, and symbols and units of measurement are listed in an appendix. A durable cover with round edges helps prevent the book from being damaged and makes it easier to handle. UPDATED coverage reflects current research relating to accuracy of testing, diagnostic values of results, and the patient care and education associated with each test. 14 NEW test entries present the latest tests and procedures with an emphasis on new, more affordable (and thus more common) genetic tests.

Mosby s Canadian Manual of Diagnostic and Laboratory Tests E Book

Author : Kathleen Deska Pagana
File Size : 23.25 MB
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The very first resource of its kind, written exclusively for Canada, Mosby’s Canadian Manual of Diagnostic and Laboratory Tests provides clear, concise coverage of more than 700 of the most commonly performed tests, with Canadian lab values, SI units, Canadian cultural considerations, and more unique Canadian content. Its many user-friendly features include an easy-to-understand writing style, full-colour illustrations, and a logical organization. Each test entry is presented in a consistent format to provide quick access to information on specimen collection, normal findings, indications, test explanation, procedure and patient care, and test results and clinical significance, as well as any applicable contraindications, potential complications, interfering factors, and related tests. UNIQUE! Test Results and Clinical Significance sections explain pathophysiology and how test results may indicate certain disease processes. Critical values are emphasized to alert you to situations requiring immediate intervention. UNIQUE! Related Tests sections list tests that provide similar information or are used to evaluate the same body system, disease process, or symptom. UNIQUE! SI units in the Normal Findings section of appropriate tests offer quick and easy reference (conventional units also included). UNIQUE! Cultural Considerations boxes highlight important aspects of working with people from the diverse cultural and racial backgrounds of the Canadian population, such as First Nations communities. Includes Canadian generic and trade drug names to comply with Health Canada and the Compendium of Pharmaceuticals and Specialties (CPS). Addresses Canadian privacy laws and legislation (including PHIPA and PIPEDA), the Canadian Labour Code, and policies for DNA collection, reporting of infections such as Chlamydia, and much more. Provides information on Canadian test-tube colouring classifications and guidelines for the correct order and process of collecting blood samples in Canada. Follows Canadian standard precautions and procedures such as those set forth by the Canadian Nuclear Safety Commission, as well as Canadian screening protocols such as those set out in the Canadian Cancer Society Screening Guidelines. Canadian statistics are provided for topics such as STDs and C. difficile. New full-colour photographs and enhanced illustrations clarify key concepts and reflect the latest procedures, equipment, and techniques. Completely updated content covers 30 new tests, including ductoscopy, thyroglobulin, lactoferrin, and human papillomavirus.