Search results for: issues-and-reviews-in-teratology

Issues and Reviews in Teratology

Author : Harold Kalter
File Size : 51.43 MB
Format : PDF, ePub
Download : 195
Read : 1135
Download »
Teratology is at once among the oldest and youngest of human preoccupations. Coincident with man's first observations of the stars were his recordings of human and animal deformities. But, such aberrancies must have occurred even earlier, for although it is one of those things-like evolution-that cannot be proven, it is nevertheless indisputable that dysmorphogenesis must have occurred from the time complex forms of life first arose on our planet; and that from the beginnings of human awareness our species was conscious of such happenings. From the earliest recordings of this fascination with the form and meaning of abnormality a tortuous but continuous line extends to modern struggles to understand and control these manifestations. And now, after long occupying an honorable but peripheral place in the halls of philosophical and scientific pursuits, teratology has quite suddenly come to take a prominent position at the hub of a complex crossroads of human concerns. This shift in its fortune has taken several forms. Fetal maldevelopment has become the concern of environmentalists, activists of various persuasions, indus trial organizations, government agencies, ethicists, parents-i. e. , individuals and groups whose actions are impelled by apprehension. Such motives are of course not without basis; the trauma of thalidomide left a scar yet raw. For still others clinicians, academics, experimentalists-the upsurge in the interest in fetal mal development is at a different level, and their pursuits are broad, taking external agents as but one of the causes of defective development.

Issues and Reviews in Teratology

Author : Harold Kalter
File Size : 34.54 MB
Format : PDF, ePub, Mobi
Download : 100
Read : 778
Download »
Teratology is at once among the oldest and youngest of human preoccupations. Coincident with man's first observations of the stars were his recordings of human and animal deformities. But, such aberrancies must have occurred even earlier, for although it is one of those things-like evolution-that cannot be proven, it is nevertheless indisputable that dysmorphogenesis must have occurred from the time complex forms of life first arose on our planet; and that from the beginnings of human awareness our species was conscious of such happenings. From the earliest recordings of this fascination with the form and meaning of abnormality a tortuous but continuous line extends to modern struggles to understand and control these manifestations. And now, after long occupying an honorable but peripheral place in the halls of philosophical and scientific pursuits, teratology has quite suddenly come to take a prominent position at the hub of a complex crossroads of human concerns. This shift in its fortune has taken several forms. Fetal maldevelopment has become the concern of environmentalists, activists of various persuasions, indus trial organizations, government agencies, ethicists, parents-i. e. , individuals and groups whose actions are impelled by apprehension. Such motives are of course not without basis; the trauma of thalidomide left a scar yet raw. For still others clinicians, academics, experimentalists-the upsurge in the interest in fetal mal development is at a different level, and their pursuits are broad, taking external agents as but one of the causes of defective development.

Issues and Reviews in Teratology

Author : H. Kalter
File Size : 34.99 MB
Format : PDF, ePub, Mobi
Download : 478
Read : 717
Download »
Why Efforts to Expand the Meaning of "Teratogen" Are Unacceptable Disagreement about nomenclature in teratology is not new. Dissent even about the very fabric of the discipline-what congenital malformations consist of-has often been voiced. Time, instead of resolving such diffi culties, has sometimes worsened them. For example, in the past it was agreed that congenital malforma tions are abnormalities of structure present at birth, but differences of opinion concerning where the line between normal and abnormal was to be drawn prevailed. It was obvious that, in order to discover the causes of congenital malformations and cast strategies for their prevention, it would be necessary to have knowledge of the baseline of their frequency, and that this required uniformity of definition of terms. Since malfor mations of primary social concern are those having grave outcomes (and are, paradoxically, also the commonest ones), it is logical that such condi tions were the first consideration of investigators and were the defects whose frequency was considered to comprise the required baseline.

Issues and Reviews in Teratology

Author : KALTER H.
File Size : 85.9 MB
Format : PDF, Docs
Download : 817
Read : 1105
Download »

Issues and Reviews in Teratology

Author : H. Kalter
File Size : 52.95 MB
Format : PDF, Kindle
Download : 362
Read : 519
Download »
Each new volume of this publication brings the privilege of expressing some of my thoughts on subjects of interest to its readers. In the past year or so public concern about environmental and societal dangers has largely turned to those of cosmic proportion-Chernobyl, the thinning ozone layer, AIDS, and the like-and thankfully our subject matter has been allowed a respite. Even the miniepidemic of craniofacial and other malformations caused by the retinoid antiacne drug Accutane made no headlines. Incidentally, this might have been a tragedy of far greater proportions had it not been nipped in the bud by the historical ground work that quickly permitted it to be recognized as due to an environ mental teratogen-the sort of fact the public and authorities inadequately appreciate. But there is a warning connected with this abeyance of media focus on teratological matters. Disquiet over cosmic imbalances will sub side as they are corrected or horrendous projections fail to materialize, and even cures for dread infectious diseases, or Puritan revolution in terdicting such plagues, will be forthcoming, and these things will occur long before congenital malformations are no more. And as the year-in and year-out recurrence of over 100,000 an nual births of seriously malformed infants in the United States alone continues to force itself on the public consciousness, we can expect a heightened demand that "a cure" be found, because "if we can land a man on the moon, if we can prevent polio, why can't we . . .

The Developing Human E Book

Author : Keith L. Moore
File Size : 82.26 MB
Format : PDF, Mobi
Download : 809
Read : 693
Download »
The Developing Human: Clinically Oriented Embryology, by Drs. Keith L. Moore, T.V.N. Persaud, and Mark G. Torchia, delivers the world’s most complete, visually rich, and clinically oriented coverage of this complex subject. Written by some of the world’s most famous anatomists, it presents week-by-week and stage-by-stage views of how fetal organs and systems develop, why and when birth defects occur, and what roles the placenta and fetal membranes play in development. Acquire a detailed grasp of human embryology with the world’s most comprehensive, richly illustrated, and clinically oriented coverage from a cadre of leading world authorities. Effectively prepare for exams with review questions and answers at the end of each chapter. Understand all of the latest advances in embryology, including normal and abnormal embryogenesis, causes of birth defects, and the role of genes in human development. See how discoveries in molecular biology have affected clinical practice, including the development of sophisticated new techniques such as recumbent DNA technology and stem cell manipulation. Prepare for the USMLE Step 1 with clinical case presentations, highlighted in special boxes, that demonstrate how embryology concepts relate to clinical practice.

Male Mediated Developmental Toxicity

Author : Andrew F. Olshan
File Size : 71.81 MB
Format : PDF, ePub
Download : 408
Read : 320
Download »
The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.

Casarett and Doull s Toxicology

Author : Louis J. Casarett
File Size : 36.65 MB
Format : PDF, Kindle
Download : 456
Read : 1089
Download »
Annotation.

Federation Proceedings

Author : Federation of American Societies for Experimental Biology
File Size : 30.63 MB
Format : PDF, ePub, Docs
Download : 108
Read : 895
Download »
Vols. for 1942- include proceedings of the American Physiological Society.

Developmental Toxicology

Author : Ronald D. Hood
File Size : 52.52 MB
Format : PDF, ePub
Download : 401
Read : 174
Download »
TECHNICAL

Toxicological Profile for Mirex and Chlordecone

Author :
File Size : 58.12 MB
Format : PDF
Download : 621
Read : 655
Download »

ATLA

Author :
File Size : 79.35 MB
Format : PDF, Kindle
Download : 957
Read : 978
Download »

The Cumulative Book Index

Author :
File Size : 57.15 MB
Format : PDF, Docs
Download : 863
Read : 248
Download »
A world list of books in the English language.

Haines and Taylor Obstetrical and Gynaecological Pathology

Author : Magnus Haines
File Size : 35.66 MB
Format : PDF
Download : 542
Read : 1193
Download »
This reference work on all aspects of gynaecological and obstetrical pathology provides descriptions of vulvular, vaginal, endometrial, tubal, cervical and ovarian pathology. It also places special emphasis on the immunopathological aspects of gynaecological and obstetrical disorders.

Teratology

Author :
File Size : 46.10 MB
Format : PDF, ePub
Download : 397
Read : 965
Download »

Morbidity and Mortality Weekly Report

Author :
File Size : 43.54 MB
Format : PDF, ePub, Mobi
Download : 641
Read : 159
Download »

Toxicological Profile for 1 1 1 trichloroethane

Author :
File Size : 40.96 MB
Format : PDF, ePub
Download : 714
Read : 232
Download »

Draft Toxicological Profile for Di n butyl Phthalate

Author :
File Size : 35.10 MB
Format : PDF, ePub, Mobi
Download : 616
Read : 942
Download »

Toxicological Profile for Chloroform

Author :
File Size : 60.46 MB
Format : PDF, ePub, Mobi
Download : 192
Read : 411
Download »

Critical Reviews in Toxicology

Author :
File Size : 31.33 MB
Format : PDF, Mobi
Download : 730
Read : 907
Download »