Search results for: nephropathy

IgA Nephropathy

Author : A.R. Clarkson
File Size : 23.66 MB
Format : PDF, ePub, Docs
Download : 270
Read : 375
Download »
IgA nephropathy has, in the course of two decades, become one of the most important renal diseases. Not only is it the most common form of glo merulonephritis seen in many countries, its increasing recognition by renal biopsy in this time has allowed sufficient study to conclude that it is also one of the most frequent causes of end-stage renal failure. The clinical features are diverse, and only in a minority do recurrent macroscopic hematuric episodes associated with an upper respiratory tract infection allow a confident clinical diagnosis. All clinicians, from community practitioners to general and specialist internists and surgeons, should be aware of its manifestations in patients of all ages. Its relationship with Henoch-Sch6nlein purpura is especially interesting. The discovery of IgA nephropathy has caused an explosion of interest and research. The disease itself (if indeed it can be regarded as a single entity rather than a syndrome) has been studied extensively by many groups and a synopsis is presented by several of the leaders in this clinical field. Parallel with the increased understanding of the renal disease, there has occurred similar incremental knowledge in such diverse fields as the structure and function of the glomerular mesangium, the biology of mucosal immu nity, and the IgA immune response. This book has collected essays on these topics that emphasize their importance in the rclation to the study of IgA nephropathy.

Diabetic Nephropathy

Author : Joris J. Roelofs
File Size : 90.9 MB
Format : PDF, ePub, Mobi
Download : 366
Read : 371
Download »
This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments. Written by leading experts in the field, it provides a comprehensive synthesis of clinical and pathophysiological aspects from a mechanism-based point of view, and reviews evidence-based treatment modalities for the prevention and management of diabetic nephropathy. In addition, closely related areas such as diabesity, diabetic eye disease and macrovascular involvement in diabetes are addressed. Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications.

Diabetic Nephropathy

Author : Jiří Syllaba
File Size : 75.67 MB
Format : PDF, ePub, Mobi
Download : 550
Read : 693
Download »
Na tomto svazku se podílí několik autorů (J. Syllaba, M. Zrůstová, J.T. Ireland, J. Opplt). Po seznámení s obecnou koncepcí a hlavními rysy práce přistupují k popisu patologie diabetické sklerózy klubíček ledvin, světelné a.

Diabetic Nephropathy

Author : E.A. Friedman
File Size : 69.95 MB
Format : PDF, Kindle
Download : 904
Read : 798
Download »
Diabetic nephropathy is a tragic illness. Its often insidious onset in the insulin dependent (type I) diabetic, typically a young adult, heralds the last act in the course of a disease that will increasingly become the dominant preoccupation in the patient's shortened life. For most type II diabetics, the beginning of clinical renal insufficiency is but a phase in a continuous deterioration that affects the integrity ofjob, marriage, and family. The nephropathic diabetic is hypertensive, has worsening retinopathy, and more often than not, is also plagued by peripheral vascular insufficiency, heart disease, gastrointestinal malfunction, and deepening depression. Until the 1980's, few type I diabetics who became uremic (because ofdiabetic nephropathy) lived for more than two years. Hardly any attained true rehabilitation. This dismal prognosis is changing substantially for the better. Research in diabetes has resulted in striking advances at both ends of the type I diabetic's natural history. In one exciting clinical trial now underway in London, Ontario, halfofchildhood diabetics treated with cyclosporine within six weeks of onset evince"permanent" disappearanceofhyperglycemia and the need for insulin. At the otherendofthe natural historyofdiabetes for the nephropathic patientwith worsening eye disease (renal-retinal syndrome), who receives a kidney transplant, patient and graft survival, two years after cadaveric kidney transplantation in type I diabetics is now equal to that of the nondiabetic.

The Balkan Nephropathy

Author : Gordon Ethelbert Ward Wolstenholme
File Size : 41.60 MB
Format : PDF, ePub, Docs
Download : 120
Read : 1131
Download »

Early and Late Mechanisms for Vomitoxin induced IgA Nephropathy

Author : Ding Yan
File Size : 32.10 MB
Format : PDF, ePub
Download : 685
Read : 1259
Download »

Alternative Murine Models for Dietary Vomitoxin induced Immune Dysregulation and IgA Nephropathy

Author : Craig Allen Banotai
File Size : 20.49 MB
Format : PDF, ePub, Docs
Download : 289
Read : 265
Download »

Diabetic Nephropathy

Author : Christoph Hasslacher
File Size : 89.34 MB
Format : PDF, ePub
Download : 908
Read : 338
Download »
This volume will focus on and emphasise the clinical relevance of diabetic nephropathy, a relatively common problem of diabetes. It affects about one in three patients with Type 1 diabetes, and left untreated can lead to a progressive decline in renal function, accompanied by retinopathy and arterial hypertension, which, in turn, leads to cardiovascular disease - a common cause of death in these patients. Diabetic Nephropathy will also provide the reader with a solid grounding in current basic and clinical research.

IgA Nephropathy Today

Author : Yasuhiko Tomino
File Size : 39.43 MB
Format : PDF, ePub, Mobi
Download : 403
Read : 561
Download »
A further step towards unraveling this mysterious disease Primary IgA nephropathy has first been described as a new disease entity almost 40 years ago. This disorder, considered to be an immune-complex-mediated glomerulonephritis, is characterized by granular deposition of IgA (mainly IgA1) and C3 in the glomerular mesangial areas and is defined as nephropathy showing proliferative changes in the glomerular mesangial cells and increases in the mesangial matrices. Apart from being one of the most common types of chronic glomerulonephritis, it is also the most frequent case of end-stage renal disease. But even though continuing efforts have gradually clarified various aspects of the pathogenesis of the disease, specific treatment is not yet available. In this publication, international nephrologists and basic scientists report the most recent data on IgA nephropathy. Starting with clinical reviews on topics such as the clinico-pathological classification, new treatment approaches, and the role of renal biopsies, the focus then shifts towards basic reviews on, for example, candidate genes, the pathogenic role of IgA receptors or immune complex formation. Updates on clinical and basic advances, discussing among other things the influence of obesity or various therapeutic approaches, make up the second part of the book. Presenting up-to-date information on this still mysterious disease, the publication at hand constitutes a valuable source of information for nephrologists, general practitioners, residents and interns.

Recent Advances in IgA Nephropathy

Author : Kar Neng Lai
File Size : 48.95 MB
Format : PDF, Mobi
Download : 994
Read : 202
Download »
IgA nephropathy is the most common primary glomerulonephritis in developed countries. The primary defect lies in the abnormalities of the IgA molecule. The disease affects all ages, mainly in the young adults, and may recur in a transplanted kidney.This outstanding volume provides a comprehensive overview of the advances in this disease over the last ten years. It covers the genetics, epidemiology, clinicopathological features, pathogenesis, prognostic mechanisms, and treatment of this unique disease. Twenty-seven chapters are written by 43 experts from 13 countries; these experts have been providing forefront scientific findings to the scientific community for the last 20 years. The book covers all clinical, pathological and molecular aspects of IgA nephropathy. This is an essential source of reference for nephrologists, internists, pathologists, and molecular biologists. It is also suitable reading for graduate students or research scientists in the field of kidney diseases.

Type 2 Diabetic Nephropathy in Japan

Author : Yasuhiko Tomino
File Size : 55.68 MB
Format : PDF, Mobi
Download : 592
Read : 1221
Download »
Type-2 diabetic nephropathy is one of the major long-term microvascular complications occurring in nearly 40% of diabetic patients in Japan. The purpose of this book is to review recent work on the genetic background, pathogenesis and treatment of this disorder and to provide the most up-to-date findings on these subjects in Japan.The pathogenesis of diabetic nephropathy includes both metabolic and / or hemodynamic factors, as well as renal hypertrophy. Hyperglycemia is necessary, but not sufficient, for its initiation and progression: The toxicity of persistent hyperglycemia results from glucose overutilization and multiple secondary effects. Moreover, diabetic nephropathy is generally considered to alter the chemical composition of the glomerular basement membrane and mesangium. At present, it is supposed that the increases in extracellular matrix accumulation due to TGF-beta activation might be related to the glomerular sclerosis in diabetic nephropathy. Although large numbers of candidate genes have been analyzed, those related to initiation and progression are still obscure in patients with type-2 diabetic nephropathy.Presenting clinical findings and issues related to laboratory analysis, this book will be of interest for nephrologists, diabetologists, pathologists, biochemists, general physicians and residents.

Pathogenesis and Treatment in IgA Nephropathy

Author : Yasuhiko Tomino
File Size : 26.70 MB
Format : PDF
Download : 377
Read : 1045
Download »
This book discusses the latest findings on the pathogenesis and treatment of IgA nephropathy. It particularly focuses on recently recognized initiation and progression factors and the varying treatment strategies in different regions, such as Asia, Europe, and the United States. More than 40 years have passed since Dr. Jean Berger first described primary IgA nephropathy (“Nephropathy with mesangial IgA-IgG deposits”) as a new disease entity. Immunohistopathologically, IgA nephropathy is characterized by the granular deposition of IgA (IgA1) and C3 in the glomerular mesangial areas with mesangial cell proliferation and the expansion of mesangial matrices. It is clear that IgA nephropathy is one of the most common types of chronic glomerulonephritis in the world. This disease may lead to end-stage kidney disease, with its enormous economic impact on healthcare everywhere. Efforts by many investigators around the world have gradually clarified various aspects of the pathogenesis and treatment of IgA nephropathy. However, there are many controversial strategies for the treatment of patients with IgA nephropathy throughout the world, as there are several limitations for treatment in each country. This volume provides nephrologists everywhere with an overview and comparison of both global and regional findings in basic and clinical fields in IgA nephropathy. It covers genetic variation, aberrant IgA1 production, and classification etiology, guidelines, and treatment goals, with all chapters written by top international researchers.

IgA Nephropathy

Author : Yasuhiko Tomino
File Size : 28.6 MB
Format : PDF, Mobi
Download : 223
Read : 1017
Download »
The author of this volume has studied IgA nephropathy for nearly 25 years, almost as long as primary IgA nephropathy has been recognized as a new disease. IgA nephropathy, considered to be an immune-complex-mediated glomerulonephri tis, is characterized by granular deposition of IgA (mainly IgA1) and C3 in the glomerular mesangial areas and is defined as nephropathy showing pro- liferative changes in the glomerular mesangial cells and increases in the mesangial matrices. Apart from being one of the most common types of chronic glomerulonephritis, it is also the most frequent case of end-stage renal disease. Since the pathogenesis of IgA nephropathy is still obscure, specific treatment is not yet available. Previous approaches have included tonsillectomy, anticoagulants, prednisolone, immunosuppressants, angiotensin-converting enzyme inhibitors and others. During his career, the author of this book has studied many aspects of IgA nephropathy, shedding much light on the mechanism of development and progression of this disease. He also undertook new treatments for patients and developed animal models for IgA nephropathy. The purpose of the present volume is to review the authors work on pathogenesis and treatment of the disease and to provide the most up-to-date findings on this subject, constituting a valuable source of information for nephrologists, general practitioners, residents and interns.

Recent Advances in IgA Nephropathy

Author : Kar Neng Lai
File Size : 68.64 MB
Format : PDF, Kindle
Download : 824
Read : 434
Download »
IgA nephropathy is the most common primary glomerulonephritis in developed countries. The primary defect lies in the abnormalities of the IgA molecule. The disease affects all ages, mainly in the young adults, and may recur in a transplanted kidney. This outstanding volume provides a comprehensive overview of the advances in this disease over the last ten years. It covers the genetics, epidemiology, clinicopathological features, pathogenesis, prognostic mechanisms, and treatment of this unique disease. Twenty-seven chapters are written by 43 experts from 13 countries; these experts have been providing forefront scientific findings to the scientific community for the last 20 years. The book covers all clinical, pathological and molecular aspects of IgA nephropathy. This is an essential source of reference for nephrologists, internists, pathologists, and molecular biologists. It is also suitable reading for graduate students or research scientists in the field of kidney diseases.

Moderately Proteinuric IgA Nephropathy in the Young

Author : Rosanna Coppo
File Size : 70.54 MB
Format : PDF
Download : 440
Read : 1186
Download »
IgA nephropathy (IgAN) is one of the most common glomerular diseases world-wide. Its natural history is consistent with a clinical onset in the first decades of life. Clinical indicators of poor prognosis are proteinuria and hypertension. Angiotensin-converting enzyme-inhibitors (ACE-I) are a promising treatment, since angiotensin II playes a key role in glomerular hypertension and permselectivity and modulates mesangial and tubular cell functions.

Diabetes and the Kidney

Author : Christoph Hasslacher
File Size : 83.18 MB
Format : PDF, ePub, Docs
Download : 919
Read : 579
Download »
Diabetes, when untreated, leads to damage to several organs within the body, particularly the kidneys. This damage may also go undetected for several years, until the later stages of kidney failure are reached, with a need for kidney replacement therapy - either dialysis or transplantation. Such progression is not inevitable. With good management, diabetes can be well controlled and kidney function can be maintained; to a certain extent, the damage can even be reversed. Diabetes and the Kidney is written for people with diabetes, their families and carers. It describes the function of the kidneys, the development of nephropathy, the ways to recognize it early and the correct way to manage it. The title emphasizes how people should take responsibility for their own health, with information on diet, giving up smoking and taking exercise. Clearly written description of kidney function, how it goes wrong in diabetic nephropathy and ways to prevent this Guidance on diet, exercise and generally encouraging people to become involved in their own health care Information on treatment of kidney disease and kidney replacement therapy

Advances in Nephropathy

Author : Thomas Rath
File Size : 39.40 MB
Format : PDF, ePub, Docs
Download : 945
Read : 441
Download »
Chronic kidney disease (CKD) is a world-wide known disease affecting up to 4% of the population with increasing figures in developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population and only a minority of patients reach end stage renal disease (ESRD) with the need for dialysis or renal transplantation; death overtakes dialysis. In nine chapters, this book focuses on different aspects related to the pathophysiology and clinical aspects of CKD, providing interesting insights into new and old biomarkers, allowing us to increase diagnostic and prognostic meaningfulness. In addition, chapters deal with new developments in glomerulopathies, but also aspects of the "tubulocentric" shift will be beneficial for the open-minded reader. Nevertheless, new insights into chronic kidney disease (CKD) and acute kidney injury (AKI) are provided.

Diabetic Nephropathy

Author : John Chan
File Size : 48.66 MB
Format : PDF, Mobi
Download : 662
Read : 1204
Download »
Internationally renowned experts have provided data on their own studies, and discuss the relative usefulness of their work in relation to diabetic nephropathy. The first section describes the novel role of intrarenal renin-angiotensin-aldosterone system (RAAS) and oxidative stress in the development of diabetic nephropathy and discusses the current and novel pharmacological interventions in the treatment of diabetic nephropathy. The second section discusses other important contributors outside of the RAAS in the pathogenesis of diabetic nephropathy including AGE/RAGE, epithelial-mesenchymal-transition (EMT) and immune cytokines. Features: Provides novel information on various pathophysiological determinants in the development of diabetic nephropathy Provides novel information on various pharmacological interventions of diabetic nephropathy

Nephropathy New Insights for the Healthcare Professional 2011 Edition

Author :
File Size : 33.70 MB
Format : PDF, ePub
Download : 240
Read : 1285
Download »
Nephropathy: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Nephropathy in a concise format. The editors have built Nephropathy: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nephropathy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nephropathy: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Nephropathy New Insights for the Healthcare Professional 2012 Edition

Author :
File Size : 68.6 MB
Format : PDF, Kindle
Download : 859
Read : 827
Download »
Nephropathy: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nephropathy. The editors have built Nephropathy: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nephropathy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nephropathy: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.