Search results for: recent-advances-in-schizophrenia


Author : Philip G. Janicak
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Schizophrenia: Recent Advances in Diagnosis and Treatment is a major addition to the literature, offering practical, comprehensive coverage of diagnosis and treatment options, genetic issues, neuroimaging, long-term management of schizophrenia, and future directions and predictions of how clinical care of schizophrenia will change. The book is divided into five sections. Section 1 summarizes the present state of knowledge about the diagnosis and treatment of schizophrenia. This includes recent changes in the DSM 5 categorization of schizophrenia and its implications for treatment. Section 2 considers recent discoveries into its pathoetiology, including the status of biological markers, genetics and neuroimaging as they relate to diagnosis and potential novel therapeutic approaches. Section 3 explores the optimization of present therapeutic approaches; novel treatments; and management of the substantial risks associated with both the illness and its present therapies. Section 4 discusses progress in the long-term management of schizophrenia, focusing on biological and psychotherapeutic strategies to improve functioning and facilitate recovery. Section 5 considers future directions and predictions of how diagnosis and treatment of schizophrenia will change. An invaluable addition to the field, Schizophrenia: Recent Advances in Diagnosis and Treatment is a definitive resource that will be of great interest to all clinicians caring for patients with schizophrenia.

Schizophrenia Research

Author : Tomiki Sumiyoshi
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Schizophrenia is a relatively common disease whose lifetime prevalence in the general population is reported to be about 1%. From the perspective of public health, the illness has been associated with serious consequences. Besides psychotic symptoms, schizophrenia is characterized by disturbances of cognitive function, which is considered to largely determine the outcome of patients. The neural and genetic substrates underlying its pathophysiology have not been fully demarcated, posing a challenge for the development of breakthrough therapeutics. This book provides key information about the latest endeavor to solve these difficulties characterizing this enigmatic disease.

Schizophrenia dementia Praecox

Author : Association for Research in Nervous and Mental Disease
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Recent Advances in the Biology of Schizophrenia

Author : Thomas A. Ban
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Recent Advances in Schizophrenia

Author : Anthony Kales
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I am honored to introduce readers to this extraordinary volume, the first in the annual International Perspectives Series: Psychiatry, Psychology, and Neurosciences. This particular volume on the Recent Advances In Schizophrenia stems from the Third Annual Pennsylvania Conference on Schizophrenia, held in March, 1988. At that international meeting, some of the most esteemed researchers in the field surveyed our current under standing of schizophrenia. Collectively, their presentations capture the excitement of a research field launching into a stage of rapid worldwide advancement. The last decade has seen an enormous refocusing of scientific effort on schizophrenia, directed, in large measure, by the National Institute of Mental Health (NIMH). Our understanding of this mysterious, disabling disorder in all its diversity has been enhanced by a host of technologies, including new neuroimaging techniques, cognitive psychology, molecular genetics, and anatomical, biochemical, and molecular neuropathology. The resulting growth spurt in our knowledge constitutes the essence of the conference and of this volume. As the following pages amply docu ment, it has been a decade of great progress, one in which we can take great pride. The science of our field has matured to the point that a major research thrust is now feasible-one likely to have enormous benefits for schizophrenic patients and their families. It is a very exciting time to be in this field and to participate in accelerating its advances.

Clinical Psychiatry Recent Advances and Future Directions

Author : David Baron
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Recent advances in clinical psychiatry are presented by David Baron and Lawrence Gross in this issue of Psychiatric Clinics. Psychiatrists will find here disorders they deal with daily in patients and topics include Advances in: Addictive disorders; Geriatric and healthy aging; Trauma and violence; PTSD; Schizophrenia; Intellectual disabilities; Neuropsychiatry, Psychopharmacology; Integrated care - psychiatry and primary care; Global and cultural psychiatry; Mood disorders. Also presented are the Future role of psychotherapy in psychiatry; Public mental health in the Affordable Care Act era; Genetics; and Diagnostic classification (DSM criteria) how they are transitioning in future - DSM V and beyond.

Recent Advances in Psychiatry from Psycho Neuro Immunology Research Autoimmunencephalitis Autoimmune Encephalopathy Mild Encephalitis

Author : Karl Bechter
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Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.


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Advances in Schizophrenia Research 2009

Author : Wagner F. Gattaz
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Schizophrenia remains an important challenge to psychiatry, with its causes and underlying brain mechanisms yet to be fully revealed. Currently available treatments are neither universally effective nor without unwanted effects. These aspects, together with the high prevalence of schizophrenia, its often debilitating nature, and the associated family and social burden, make this mental disorder one of the most complex public health issues of our times. The purpose of the Advances in Schizophrenia Research series is to provide comprehensive periodic reviews of the wide range of research studies carried out around the world, with the dual purpose of solving the schizophrenia puzzle, and providing clues to new forms of treatment and prevention for this disorder. A special feature of the series is its broad scope, virtually encompassing all fields of schizophrenia research: epidemiology and risk factors; psychopathology; diagnostic boundaries; cognition; outcome and prognosis; pathophysiology; genetics; pharmacological and psychological forms of treatment and rehabilitation; community care; and stigmatization.

Recent Advances in Biological Psychiatry

Author : Joseph Wortis
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A method of behavioral control which utilizes nutritive sucking as the operant has been evolved in our laboratory. Using this technique we studied the role of arousal and learning in the development of environ mental control over earliest feeding behavior. Few of the infants in our studies were able to coordinate their sucking behavior to arbitrary operant-discrimination schedules, but when the individual pattern of suck ing was taken into consideration, some infants rapidly adapted to the reinforcement schedule. Data from various reinforcement schedules suggest that earliest mothering involves a mutual adaptation in which the nurturing environment approximates and then entrains the infant's feeding behavior by a perceptive manipulation of the infant's state of arousal. Coordination between the infant and its environment sets the stage for associative learning, which develops following maturation of the infant's discriminative and response capacities. The process of behavioral acquisition begins with unconditioned feeding responses, which are transformed into complex learned behavior through the mediation of an appropriately reinforcing environment. The infants studied showed individual differences in susceptibility to environmental control and in response to frustration. The relative importance of arousal and learning as determinants of infant behavior are discussed and a hypothetical model for the earliest mother-infant relationship is proposed.

Insight and Psychosis

Author : Xavier Francisco Amador
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Recent advances in the cognitive and neurosciences have provided an ideal opportunity to synthesize the work from the varied disciplines studying self-awareness. By bringing together hitherto disparate approaches to the problem of insight in psychosis, this volume provides a deeper understanding of the phenomenology, origins, and clinical implications of insight. The chapters are written by an international panel of experts in their fields. The authors describe how their own orientations and work have contributed to illuminating the questions regarding the nature of insight in psychosis, while remaining mindful of the overarching goal of this book: to bring together in a single volume the most important and up-to-date exemplars of the diverse approaches to understanding insight and its role in the treatment of psychotic disorders.

Advances in Neuroscience and Schizophrenia

Author : A.H. Tuma
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Schizophrenia has been the subject of intense research interest in recent years, as investigators have explored the biological bases for the disorder and for various approaches to its diagnosis and treatment. This volume focuses on three aspects of such recent research connecting basic neuroscience to schizophrenia. In one, Professors Budinger, Gur, and Pettegrew provide critical reviews of brain imaging studies as they relate to cognitive behaviour functions in schizophrenia. In the second, Professors Goldmann-Rakic, Lewis, and Tassin discuss monoamine systems and their varied role in prefontal cortical circuitry and function. In the third, Professors Deutsch, Gerfen, and Grace discuss the structure, organization, and function of the basal ganglia, as they relate to schizophrenia and the mechanisms of neuroleptic action. These papers were presented at an interdisciplinary workshop on the subject at the University of Pittsburgh, in May 1991, and the discussion between the authors and other panelists in basic and clinical sciences are included in this volume as well. The presentation of these diverse approaches in an integrated fashion provides the reader with a unique perspective and a wealth of new questions for future collaborative research.


Author : Daniel R. Weinberger
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Schizophrenia is one of the most complex and disabling diseases to affect mankind. Relatively little is known about its nature and its origins, and available treatments are inadequate for most patients. As a result, there are inevitable controversies about what causes it, how to diagnose it, and how best to treat it. However, in the past decade, there has been an explosion of new research, with dramatic discoveries involving genetic etiology and epidemiological risk factors. There has also been a catalog of new drugs coming to market, and controversy about the relative advantages and disadvantages of newer compared with older therapies. In addition, developing technologies in genomics, molecular biology and neuroimaging provide streams of new information. This book represents a definitive, essential, and up-to-date reference text on schizophrenia. It extensively and critically digests and clarifies recent advances and places them within a clinical context. The Editors (one American and one British), highly respected clinical psychiatrists and researchers and acknowledged experts on schizophrenia, have again assembled an outstanding group of contributors from the USA, UK, Europe and Australia, It will be of value to practising psychiatrists and to trainees, as well as to clinical and neuroscience researchers interested in keeping up with this field or coming into it. The book consists of four sections: descriptive aspects, biological aspects, physical treatments, and psychological and social aspects. It reviews the theoretical controversies over symptomatology, classification and aetiology (particularly pertinent as DSM-V is being developed), the relationship of schizophrenia to the other psychoses, the significance of positive and negative symptoms and pre-morbid personality. It describes a variety of approaches to integrating the vast research data about schizophrenia, including neurodevelopmental, genetic, pharmacological, brain imaging and psychological findings. The biological treatment section reviews the comparative efficacy of various drugs, the management of drug-resistant patients and both neurological and metabolic complications. The final section looks at psychological therapies, social outcomes, and the economics of schizophrenia. Highly Commended in the Psychiatry section of the 2012 BMA Book Awards.

The Year in Schizophrenia

Author : Thaker
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Schizophrenic disorders, of which at least five separate kinds are now recognised, remain difficult to diagnose and still harder to treat. This second volume reviews the most important work published in the last year, with expert comment and analysis from two of the leading authorities in the field. The editors review the latest advances in our understanding of the biochemical basis of the disease, its detection and diagnosis, and its relationship to other co-existent mental illness. There is up-to-date coverage of psychopharmacological agents and expert comment on recent advances in neurological aspects. In addition, this volume also includes discussion of cognitive and negative symptoms therapies, and psychosocial treatments. The Year in Schizophrenia enables the reader to keep up to date with the therapeutic options available, and maintain a better informed perspective on current opinion. It should find a place in the office of every doctor involved in the study and treatment of this complex and challenging disorder. BENEFITS: Evaluation and critical appraisal of the full range of published literature in the field Key papers for practice identified and summarised Single user-friendly volume Draws on the experience of leading authorities

Schizophrenia 1993

Author : David Shore
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Schizophrenia remains the most puzzling, chronic, and disabling of the severe mental disorders. Presents recent developments in research: diagnosis and classification, relation of symptoms to cognitive deficits, information processing and attention dysfunctions, genetics, psychopharmacologic treatment, tardive dyskinesia, psychosocial treatment, neuroimaging, infection and autoimmunity, neurochemistry and neuroendocrinology, and neuropathology. A nontechnical summary of each major area proceeds the articles.

The Mosaic of Contemporary Psychiatry in Perspective

Author : Anthony Kales
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Psychiatry has undergone a dynamic evolution in the last 40 years, an evolution to which Dr. Louis West made many contributions. Psychiatry today and Dr. West's career are intertwined in a mosaic of interaction. It is therefore fitting that this compilation of essays in honor of Dr. West is entitled The Mosaic of Contemporary Psychiatry: Current Perspectives. The papers collectively form a snapshot of the field of psychiatry today. Each chapter offers a historical perspective of the topic discussed, followed by a description of modern day issues and a look at the future of psychiatry. This book will enhance the knowledge and technical skills of psychiatrists as well as other clinicians in the mental health care field.


Author : Allan Tasman
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Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at featuring PDFs of each chapter and downloadable images


Author : April Hargreaves
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This is a series of texts that introduces the reader to some of the more recent advances in schizophrenia research. It is concerned with questioning the role of the immune system in the aetiology and course of the disorder, as well as investigating the efficacy of some of the available treatments for schizophrenia. Edited by a leading scholar in the field, and written by researchers at the cutting edge of these developments, each chapter provides details of original works and their theoretical and empirical impact. The theme of cognition is prevalent throughout the book. As a core deficit in schizophrenia, cognition proves to be fundamental to both the mechanisms underlying the disorder, and the treatments used to alleviate symptomatology. It is evident in all subpopulations of schizophrenia patients explored in this collection -- from those with early onset schizophrenia, to those being treated in forensic mental health services -- and its importance throughout the lifespan of individuals with schizophrenia is highlighted. With a focus on a practical understanding of schizophrenia, this book will be of value to all researchers, psychiatrists and therapists with a clinical or research interest in this subject.

The Pharmacology of Neurogenesis and Neuroenhancement

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Currently, few drugs are available for the effective treatment of neurodegenerative diseases and neurodevelopmental disorders. Recent advances in neuroscience research offer hope that future strategies for treating these brain disorders will include neurogenesis and neuroenhancement as therapeutic endpoints. This volume reviews cutting-edge findings related to the pharmacological aspects of neurogenesis and neuroprotection. A broad range of topics are covered from basic lab bench research to drug discovery efforts and important clinical issues. This collection of reviews is a perfect way to become acquainted with these exciting new fields in the space of a single volume. Chapters are written with a general audience in mind, but with enough high-level discussion to appeal to specialists and experts as well. The authors have done an excellent job of challenging current paradigms and pushing the boundaries of exploration in keeping with the pioneering spirit that gave rise to these emerging areas of research. Consequently, this will be an indispensable resource for many years to come. Provides state-of-the-art reviews spanning significant emerging fields Discusses future directions and questions for future studies Includes informative illustrations

Recent Advances in Neuropsycho Pharmacology

Author : B. Angrist
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Recent Advances In Neuropsychopharmacology contains selected papers from the 12th Congress of the Collegium Internationale Neuro-Psychopharmacologicum held in Gõteborg, Sweden, 22-26 June 1980. The 47 papers in the volume are organized into six parts. The papers in Part I deal with the subject of psychostimulants in psychiatric research. Topics covered include the effect of chronic d-amphetamine and chronic apomorphine treatment on non-human primate social and solitary behavior; and the behavioral effects of dopamine agonists. Part II assesses the prescription of psychotropic drugs by general practitioners. Part III examines blood platelets as a model system for central monoaminergic neurons. Part IV focuses on anxiety pathways in the brain. Part V considers prospects for a biochemical classification system in psychiatry. Part VI presents pharmacokinetic studies of psychotropic drugs. Part VI contains two papers on the renal function and renal histology of lithium patients on maintenance lithium therapy and pre-lithium patients; and the treatment of refractory schizophrenia.