Search results for: the-genetics-of-cardiovascular-disease

The Genetics of Cardiovascular Disease

Author : Mary Ella Mascia Pierpont
File Size : 79.31 MB
Format : PDF
Download : 303
Read : 874
Download »
Over the past 25 years, the growing impor cardiovascular. We hope that by having this tance of genetic factors in the basic understand compilation of cardiovascular diseases in one ing of human cardiovascular disease has become source, it will be of value to all who are involved apparent. Prior to this time, there was an era in the care of patients with cardiovascular dis when cardiovascular disease was first viewed at ease or their families. the diagnostic level followed by an era when The first six chapters of this book delineate cardiovascular disease was viewed at a treatment conditions related to congenital cardiac mal level. The first era occurred at the turn of the formations. Their etiology is not precisely century with the first clinical recognition of known, so we have included chapters that dis symptoms and patterns for diagnosis of car cuss many aspects of congenital cardiac mal diovascular diseases. The development of formations. The first chapter provides discus diagnostic methodology, such as radiographic sion of mechanisms of maldevelopment of the studies and electrocardiography, led to marked heart. We believe that these mechanisms pro changes in our understanding of cardiovascular vide a basis for understanding the genetic and disease. This era was followed by improved environmental factors which operate to produce methods of medical treatment, introduction congenital cardiac malformations. Chapter 2 describes the occurrence of con of medication such as antibiotics, and more genital cardiac malformations in families and sophisticated surgical techniques.

Cardiovascular Diseases

Author : Nikolaos Papageorgiou
File Size : 40.74 MB
Format : PDF, Kindle
Download : 483
Read : 245
Download »
Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and Their Interaction covers the special heritability characteristics and identifying genetic and environmental contributions to cardiovascular health. This important reference provides an overview of the genetic basis of cardiovascular disease and its risk factors. Included are important topics, ranging from lifestyle choices, risk factors, and exposure, to pollutants and chemicals. Also covered are the influences of Mendelian traits and familial aggregation and the interactions and interrelationships between genetics and environmental factors which, when compared, provide a sound understanding of the interplay between inherited and acquired risk factors. The book provides a much needed reference for this rapidly growing field of study. By combining the latest research within the structured chapters of this reference, a better understanding of genetic and environmental contribution to cardiovascular disease is found, helping to substantiate further investigations in the field and design prevention and treatment strategies. Provides an overview of the genetic basis of cardiovascular disease and its risk factors Reviews several large population-based studies which indicate that exposure to several environmental factors may increase CVD morbidity and mortality, exploring the plausibility of this association by data from animal studies Reflects on future studies to help understanding the role of genes and environmental factors in the development and progression of cardiovascular disease

Genetic Causes of Cardiac Disease

Author : Jeanette Erdmann
File Size : 48.38 MB
Format : PDF, Kindle
Download : 146
Read : 880
Download »
This book provides a comprehensive summary of the latest developments in the field of the genomics of cardiac disease. Written and edited by leading clinicians and scientists involved in the analysis and therapy of genetic cardiac disorders, it discusses the genetic causes of a variety of cardiac diseases, such as the complex genetics and etiology of congenital heart diseases. It also explores sex differences in prevalent diseases, genetics-based therapeutic strategies and the use of various animal models and alternatives. The book is intended for research scientists and clinical scientists in the cardiovascular field, human geneticists and cardiologists.

Cardiovascular Diseases

Author : James J. Nora
File Size : 45.66 MB
Format : PDF, Mobi
Download : 904
Read : 228
Download »
Knowledge of what causes cardiovascular diseases has progressed at a pace that challenges not only the student, but the physician and the research scientist. And while there is scientific merit in discovering the etiology of any disease, the ultimate goal is to apply what we learn to the treatment and possibly to the prevention of the diseases being studied. In this volume, the authors propose to bring together what is understood about the causes and prevention of cardiovascular diseases in individuals, families and societies. Their first theme, variations of which occur throughout the work, is that cardiovascular diseases are familial. The volume also recognizes that genetic factors for most cardiovascular diseases interact in important, if not critical, ways with the environment. Epidemiology and the genetic-environmental interaction are of major consequence. The authors' goal is as much to inspire stimulating questions as to provide a concise resource of current information.

Genetics of Cardiovascular Disease

Author :
File Size : 24.25 MB
Format : PDF, ePub
Download : 347
Read : 462
Download »
This volume of the esteemed Progress in Molecular Biology and Translational Science series focuses on cutting-edge research related to the genetics of cardiovascular disease. Written by top experts in the field, this volume covers a range of topics, including: Genetic models of atherosclerosis MicroRNAs in cardiovascular disease The role of the transcription factor KLF2 in vascular development and disease Zebrafish as models of cardiovascular disease and hematopoietic development Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. The authors are all experts in the field The reviews are in themselves comprehensive Each topic has the potential to lead to advances in therapy of cardiovascular disease

Medical Genetics of Cardiovascular Disease

Author : Garden Grove Garden Grove Press
File Size : 81.54 MB
Format : PDF
Download : 852
Read : 859
Download »
This article collection reviews the medical genetics of cardiovascular disease and includes 20 papers by various authors. Topics include: The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3; Sex-differential genetic effect of phosphodiesterase 4D (PDE4D) on carotid atherosclerosis; The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis; Immunity, atherosclerosis and cardiovascular disease; Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE −/− mice; Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis; High fat diet induced atherosclerosis is accompanied with low colonic bacterial diversity and altered abundances that correlates with plaque size, plasma A-FABP and cholesterol: a pilot study of high fat diet and its intervention with Lactobacillus rhamnosus GG (LGG) or telmisartan in ApoE −/− mice; Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography; CCR5 facilitates endothelial progenitor cell recruitment and promotes the stabilization of atherosclerotic plaques in ApoE −/− mice; Activity of peroxisomal enzymes, and levels of polyamines in LPA-transgenic mice on two different diets; Role of NOD2/CARD15 in coronary heart disease;Metabonomics-based omics study and atherosclerosis; Apolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes; Controlling the angiogenic switch in developing atherosclerotic plaques: Possible targets for therapeutic intervention; Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke; The association of functional polymorphisms in genes encoding growth factors for endothelial cells and smooth muscle cells with the severity of coronary artery disease; Monocytes/macrophages activation contributes to b-gamma-glutamyltransferase accumulation inside atherosclerotic plaques; Clinical significance of macrophage phenotypes in cardiovascular disease; Association of apolipoprotein E polymorphism with plasma lipid disorders, independent of obesity-related traits in Vietnamese children; Innate immunity and monocyte-macrophage activation in atherosclerosis. Proceeds from the sale of this book go to the support of an elderly disabled person.

Molecular Basis of Cardiovascular Disease

Author : Kenneth R. Chien
File Size : 81.71 MB
Format : PDF, ePub, Docs
Download : 419
Read : 644
Download »
The 2nd Edition of this heralded companion to Braunwald's Heart Disease explores the molecular mechanisms of cardiology and the scientific advances that are changing the practice of cardiology today. International experts discuss the role of genetics in cardiovascular disease · the molecular basis of ischemic disease, thrombosis and hypertension · genetic mapping approaches to inherited disorders · biologically targeted agents for hypertension and heart failure · and much more. Abundant figures and tables illustrate key concepts. Addresses most common cardiovascular problems from a molecular standpoint. Explores developing treatments for cardiovascular problems based on genetics. Provides references to Braunwald's Heart Disease, 6th Edition Examines today's cutting edge advances in molecular cardiology and the future of gene therapy, Examines the implications of cellular cholesterol metabolism in health and disease. Delivers up-to-date information on understanding the origin of inherited disease. With 55 additional contributing experts.

Nutrition Genetics and Cardiovascular Disease

Author : Marwan El Ghoch
File Size : 82.75 MB
Format : PDF, ePub
Download : 221
Read : 989
Download »
Cardiovascular diseases are the first cause of death worldwide, in which genetic and environmental factors seem to play a determinant role. In fact, several lifestyle (i.e., dietary, physical inactivity) factors and nutritional-related diseases (i.e., obesity, type 2 diabetes) are strongly associated with cardiovascular diseases. Moreover, genome-wide association studies have also identified numerous genomic loci that determine susceptibility to cardiovascular events. Therefore, nutrition and genetics seem to interact in predisposing an individual to cardiovascular diseases. This book provides a presentation of recent advances in knowledge on nutrition, genetics, and cardiovascular disease coming from diverse scientific disciplines.

Inherited Cardiac Disease

Author : Perry Elliott
File Size : 25.71 MB
Format : PDF, Kindle
Download : 967
Read : 1050
Download »
Many heart conditions are inherited and if not diagnosed and managed appropriately place the patient at risk of blackouts, weakening of the heart, or sudden death.While individually uncommon, inherited diseases of the cardiovascular system collectively represent a major health burden. Current recommendations suggest that individuals and families affected by inherited cardiovascular diseases should have access to specialist care in the form of multidisciplinary teams, with particular knowledge and experience in the diagnosis and management of these conditions. As a result, multidisciplinary services for inherited cardiovascular diseases, involving cardiologists, clinical geneticists, specialist nurses and genetic counsellors, are being developed throughout Europe. Inherited Cardiac Disease provides healthcare specialists involved in the diagnosis and treatment of inherited cardiovascular disorders with a clinically relevant summary of genetic diseases and readily accessible information that can be used in everyday practice. Containing summaries of most common inherited cardiovascular disorders and describing cardiomyopathies, inherited arrhythmia syndromes, and other inherited cardiovascular syndromes with a focus on aetiology, presentation and management, it also provides the non-specialist with a detailed knowledge of inherited cardiovascular diseases, from the fundamentals of molecular biology and genetic testing to the detailed clinical information relevant to patient management.

The Genetics of Cardiovascular Disease Risk Factors in American Indians from the Strong Heart Family Study Dakota Center

Author : Kari E. North
File Size : 62.23 MB
Format : PDF, Kindle
Download : 749
Read : 1145
Download »