Search results for: understanding-brain-aging-and-dementia

Understanding Brain Aging and Dementia

Author : Lawrence J. Whalley
File Size : 53.37 MB
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The life course method compares an individual's long-life and late-life behaviors to gauge one's mental decay. Arguing the life course approach is the best and simplest model for tracking mental development, Lawrence J. Whalley unlocks the mysteries of brain functionality, illuminating the processes that affect the brain during aging, the causes behind these changes, and effective coping strategies. Whalley identifies the genetic factors that determine the pace of aging and the behaviors, starting in childhood, that influence how we age. Through vignettes, charts, and tables, he composes an accessible book for patients, family members, and caretakers struggling to make sense of a complex experience.

Understanding Brain Aging

Author : Hans J. Grabe
File Size : 56.38 MB
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Application of Pattern Analysis in Understanding Brain Aging associated Symptoms and Alzheimer s Disease Using Functional MRI

Author : Wang, Xixi
File Size : 57.29 MB
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"Brain aging is accompanied with multiple symptoms including memory deficits, executive dysfunctions, depression, stress dysregulation, etc. These symptoms may result in serial adverse consequences, including cognitive decline, poor quality of life, reduced participation in intellectually beneficial activities, or mobility restriction. Moreover, abnormal aging that accompanies neuropathological changes can lead to dementia, such as Alzheimer's disease (AD). Investigating how these brain-aging associated symptoms precede incident dementia, such as AD, is the first step in the early detection and prevention of AD for the aging population. The serial studies herein focused on the restingstate functional magnetic resonance imaging data as a way to understand the aging brain. Multivariate pattern analysis models were developed to characterize the profile of brain function that are related to aging-associated cognitive, behavioral, and psychological symptoms. The relationships between the brain function profile and AD pathological measurements were also examined across different clinical phenotypes. First, a set of brain regions whose amplitudes of low-frequency activation patterns were identified, distinguishing Supernormals (older adults with longitudinally excellent cognitive performance) from normal agers. Second, a shared neural circuit whose functional connectivity patterns was revealed, predicting multiple behavioral disturbances in patients with AD and amnestic mild cognitive impairment (aMCI), a group at high risk for AD. Third, the inter-network patterns whose correlations between functional connectomes before and after an acute stress task were compared. The correspondence between the two sets of inter-network patterns in stress regulation was disrupted in aMCI group when compared with cognitively normal controls. Taken together, the in-depth characterization of brain aging functional profile, based on the relevant symptoms, across the cognitive aging spectrum (from normal cognitive aging to dementia, or to excellent cognitive aging) help lay the foundation for developing computational model-based biomarkers for early detection of AD."--Pages xi-xii.

The Aging Brain and Senile Dementia

Author : K. Nandy
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There are currently about 21 million people over 6S years in the United States and over a million of them suffer from a severe degree of mental impairment. This number will undoubtedly increase as more and more people attain their full lifespan. The Veterans Administration is acutely aware of this problem in the population it serves. Currently, there are about 31 million veterans in the United States. About 13 percent of these veterans are over 6S years of age and the number is expected to increase to 40 percent by the turn of the century. In recognition of the pressing need to address this problem, eight Geriatric Research, Educational and Clinical Centers (GRECC) have been established under the auspices of the Veterans Administration and the guiding spirit of Dr. Paul Haber, Assistant Chief Medical Director for Professional Services, Veterans Administration. The purpose of these centers is to develop a better understanding of the complex biomedical and socio-economic problems of the aged in general and to enhance the quality of life of the older veterans in particular o Gerontologists working towards a better understanding of the aging process and better care of the aged have made major progress in the biomedical field in the last decade. Among the efforts made by the Veterans Administration, the department of Extended Care and Academic Affairs have sponsored a number of symposia in the field of Gerontology.

Healthy Brain Aging Evidence Based Methods to Preserve Brain Function and Prevent Dementia An issue of Clinics in Geriatric Medicine E Book

Author : Abhilash K. Desai
File Size : 39.15 MB
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This issue examines what is a healthy aging brain and covers preventive measures for succesful cognitive aging. Topics covered include: A road map to healthy aging brain; Cardiovascular risk factors, cerebrovascular disease burden and healthy aging brain; Healthy aging brain: Impact of head injury, alcohol and environmental toxins; Healthy aging brain: What has sleep go to do with it?; Endocrine aspects of healthy aging brain; Healthy aging brain: Role of exercise and physically active lifestyle; Healthy aging brain: Role of nutrition and nutritional supplements; Healthy aging brain: Role of cognitive reserve, cognitive stimulation and cognitive exercises; Healthy aging brain: Impact of positive and negative emotions; Dementia risk predictor. Are we there yet?; Potential future neuroprotective therapies for neurodegenerative disorders and stroke; Healthy aging brain: Importance of promoting resilience and creativity.

The Aging Brain

Author : Lawrence J. Whalley
File Size : 41.71 MB
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A Scottish professor of mental health explores the brain's aging process and offers advice on how to slow down mental detoriation and prevent other effects of aging.

The Aging Brain

Author : Timothy R. MD Jennings
File Size : 61.81 MB
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While growing older is inevitable, many of the troubles we associate with aging--including dementia, disability, and an increased dependence on others--are not. The choices we make now can help us to maintain our vitality, a sharp mind, and our independence as we age. Filled with simple, everyday actions we can take to avoid disease, promote vitality, and prevent dementia and late onset Alzheimer's, The Aging Brain is an easy-to-use guide to maintaining brain and body health throughout our lives. Based on solid, up-to-date scientific research, the interventions explained in this book not only prevent progression toward dementia even in those who have already shown mild cognitive impairment, they also reduce disability and depression and keep people living independently longer than those who do not practice these methods. For anyone hoping to slow the aging process, as well as anyone who acts as a caregiver to someone at risk of or already beginning to suffer from dementia and other age-related diseases, this book offers a hopeful, healthy way forward.

Brain Aging and Therapeutic Interventions

Author : Mahendra K. Thakur
File Size : 36.1 MB
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This book brings together most up-to-date information on different aspects of brain aging and on the strategies for intervention and therapy of age-related brain disorders. It includes 18 chapters by leading researchers, and each chapter is a comprehensive and critical review of the topic in question, discusses the current scenario and focuses on future perspectives. The target readership is the undergraduate and graduate students in the universities, in medical and nursing colleges, along with the post-graduate researchers and practicing clinicians who would like to know about the latest developments in the field of neurodegenerative disorders and their therapeutic interventions. This book will be of much interest to pharmaceutical, nutrition and healthcare industry for an easy access to accurate and reliable information in the field of aging research and intervention.

Cerebrospinal Fluid in Neurologic Disorders

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Cerebrospinal Fluid in Neurologic Disorders, Volume 146 provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker. The second part addresses the main purpose of the volume, describing CSF from a research perspective in context with the most important diagnostic entities in neurology. The book's authors provide insight into the current understanding of CSF changes in these various conditions and what it tells us about the nature of neurological diseases. Furthermore, methodological aspects are discussed, as are shortcomings that need to be addressed. Finally, the book provides an outlook for potential directions that can be explored to improve the various aspects of CSF research with the ultimate goal of being incorporated in clinical practice. Provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker Addresses relevant research in context with the most important diagnostic entities in neurology Edited by leading authors in CSF research from around the globe, presenting the broadest, most expert coverage available

Assessments Treatments and Modeling in Aging and Neurological Disease

Author : Colin R. Martin
File Size : 39.29 MB
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Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer’s, stroke and multiple sclerosis. Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging Features sections on diagnosis and biomarkers of neurological aging, Alzheimer’s and stroke Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations Includes more than 500 illustrations and tables