Search results for: understanding-sickle-cell-disease

Understanding Sickle Cell Disease

Author : Miriam Bloom
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Although more is known about sickle cell disease than about any other inherited disease, no cure for it exists. In America alone, about one in 375 who are of African ancestry is born with sickle cell disease. A smaller number of Americans descended from families from the Mediterranean area, the Middle East, and India also are affected. In addition, about eight percent of black Americans who do not suffer from the disease itself carry the gene for it that can be transmitted to their children. Sickle cell disease is of enormous biological, social, and historic importance. It was first described in medical literature almost a century ago. Improvements during the past two decades in our understanding of the disease and in medical care are permitting those afflicted to live longer, more comfortable and more productive lives. This book was written for all who are interested in this disease—those who have it, their families, the carriers of the sickle cell gene, teachers, and those who wish to update their information about it. This overview of sickle cell disease explains what it is and how it is inherited, as well as the relationship between the sickle cell gene and its geographic origins, the way the gene has been spread throughout history, and the effect of sickle cell hemoglobin on red blood cells that carry it. Understanding Sickle Cell Disease describes the variety of symptoms in both children and adults and details the emotional aspects of the disease. Of particular interest is a chapter on the care, especially the home care, of those who are affected. This book explains how it is possible today for couples carrying the genes to raise families free of the disease. Although there is no known cure for sickle cell disease, there is little doubt that one will ultimately be devised. This volume surveys current research efforts and the promise they hold.

Sickle Cell Disease

Author : Phill Jones
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Describes what scientists currently know about the relationship between genes and sickle cell disease, touching on technologies and experimental methods.

Understanding Sickle Cell Disease

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Hope and Destiny

Author : Allan F. Platt
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Explains how sickle cell anemia is inherited, describes its symptoms and treatment, and discusses the search for a cure.

Sickle Cell Disease

Author : Graham R. Serjeant
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Sickle cell disease is one of the 'grand' diseases in the terminology of Victorian pathology, because its widespread and multitudinous manifestations may affect any organ system in the body. It has served as a model of molecular disease being one of the first genetic disorders to be explainedat the molecular level. Since publication of the Second Edition, however, further advances have been made. Much has been learnt about the causes of variability in the natural history of the disease and of the reasons why there are such marked variations in the patterns of morbidity and mortality.As Director of The Jamaican Sickle Cell Unit, Graham Serjeant and his colleagues have shown the disease to be extremely variable ranging from a severe clinical course with death in early childhood to mildly affected patients living to the age of 80 years. This extreme variability within a singlegenotype implies that other factors, both genetic and environmental, must influence expression of the disease. This new edition contains many new references and incorporates the latest thinking on the biology of the disease and the best practice in its management.

Psychosocial Aspects of Sickle Cell Disease

Author : Kermit B. Nash
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Psychosocial Aspects of Sickle Cell Disease presents the most current evaluations and research on biopsychosocial influence and interventions for persons with sickle cell disease. A major step forward in better understanding sickle cell and its ramifications, this innovative book is the first to use the biopsychosocial model as its frame of reference. This model takes into account the biological, psychological, and social influences on persons with sickle cell. The interdisciplinary research in this book begins the process of defining effective comprehensive care programs for those affected by sickle cell disease. This important book consolidates the available research on this topic for busy clinicians and for researchers doing further investigation in this area. This is the first interdisciplinary group effort to collaborate on a holistic approach to comprehensive care for the sickle cell population. Psychosocial Aspects of Sickle Cell Disease promotes team effort and systematically explores the quality of life issues confronting practitioners and service providers. This groundbreaking book answers practitioners'questions regarding service provision, program development, and further research in the psychosocial issues of sickle cell disease. Included among the chapters are examinations of such issues as: effects of sickle cell disease over the lifespan school adjustment family relations adolescents mutual support and self-help adult population emergency services policy issues future research directions and methodology for studying sickle cell disease All experts in the human services profession will find this comprehensive information on psychosocial issues invaluable when facing issues such as medical treatment for patients, education about sickle cell disease, counseling, pain management therapy, and occupational therapy, and support services such as housing, transportation, legal services, recreational services, and financial services. Health educators, guidance counselors, nurses, physicians, psychiatrists, psychologists, and social workers will find the information in Psychosocial Aspects of Sickle Cell Disease critical to a comprehensive understanding of the individual affected by sickle cell disease, and ultimately to the development of comprehensive care.

African American Women s Health and Social Issues

Author : Catherine Fisher Collins
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Spotlights major health issues facing African American women and the social ills that affect their longevity.

Sickle Cell Anemia

Author : Judy Monroe Peterson
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Describes sickle cell anemia, including the history of the disease, how it is treated, and the current medical research towards finding a cure.

Sickle Cell Anemia

Author : Fernando Ferreira Costa
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Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.

Sickle Cell Simply Explained

Author : Dr. John Koramoa
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Sickle cell disease is the most common genetic disease worldwide. For a person to suffer the disease, he or she has to inherit the faulty gene from each parent. In the past, sufferers of sickle cell anemia survived for a few years only and at present there is no readily available cure. However, with proper management, sufferers can live comfortable lives and for many years. Life-style measures are paramount and are referred to in some detail in the book. When only one sickle cell gene is inherited by a person with normal hemoglobin, the conditions is referred to as the carrier state or the trait. Individuals with the trait have no medical problems under normal conditions of life. This is how the gene has been able to survive and be passed on from generation to generation. Sickle cell disease, which was once thought to be restricted to only a few areas, especially among Black people, is now known to be worldwide and has been described as a world health problem.

Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease An Issue of Hematology Oncology Clinics

Author : Elliot Vichinsky
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This issue of Hematology/Oncology Clinics, guest edited by Dr. Elliott Vichinsky, is devoted to Sickle Cell Disease, and focuses on pathophysiology of hemoglobinopathies, therapeutic targets, and new approaches to correcting ineffective erythropoiesis and iron dysregulation. Articles in this issue include Polymerization and red cell membrane changes; Overview on reperfusion injury in the pathophysiology of SCD; Regulation of ineffective erythropoiesis in iron metabolism; Altering oxygen affinity; Cellular adhesion and the endothelium; Arginine therapy; Role of the hemostatic system on SCD pathophysiology and potential therapeutics; Adenosine signaling and novel therapies; New approaches to correcting ineffective erythropoiesis and iron dysregulation; New approaches to correcting ineffective erythropoiesis and iron dysregulation; Fetal hemoglobin induction; Gene therapy for hemoglobinopathies; and Oxidative injury and the role of antioxidant therapy.

Sickle Cell Anemia Modern Trends in Treatment

Author : Intsar S. Waked
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Sickle cell disease (SCD), an inherited hemolytic anemia, is associated with multiple acute and chronic complications such as painful vasoocclusive events, cerebral vasculopathy, priapism, and renal or lung disease. These complications are variable and unpredictable, and can be associated with significant morbidity and poor quality of life. This book covers several areas regarding pathology, diagnosis, complications, signs, symptoms and medical treatments. There are few studies in literature on the role of physiotherapy as a resource to prevent and treat locomotor system disorders, respiratory problems and painful crises in SCD individuals. This book highlights the role of physiotherapy in sickle cell anemia. A comprehensive and authoritative monograph, this book will be equally interesting to both established researchers and to graduate students interested in both genetics and the physical therapy field.

In the Blood

Author : Melbourne Tapper
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Relying on hospital records, biochemical tests, case studies, and medical texts, the author argues that the discovery and scientific analysis of sickle cell anemia were shaped by racism against blacks and helped to perpetuate the belief in blacks' inferiority. UP.

Sickle Cell Anemia

Author : Ruth Bjorklund
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Provides comprehensive information on the causes, treatment, and history of sickle cell anemia.

Black Girls and Adolescents Facing the Challenges

Author : Catherine Fisher Collins
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This one-of-a kind book challenges the current thinking about black girls to show how America has failed them—and what can be done to make their lives better. • Provides the first research work on this topic • Covers health (physical, mental, and sexual), education, crime/criminal justice, and parenting as they affect black teen girls and adolescents • Features contributors from a broad range of fields, including psychology, biology, criminal justice, sociology, spirituality, law, medicine, and popular culture • Examines characteristics of at-risk girls and the lure of the "bad girl" image • Clarifies what parents/mentors and others can do to help these girls and teens live happy, healthy, more rewarding lives

Let s Talk about Sickle Cell Anemia

Author : Melanie Apel Gordon
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A simple introduction to sickle cell anemia, describing its symptoms, its effects on the body, and how to cope with this disease.

Disorders of Hemoglobin

Author : Martin H. Steinberg
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Disorders of Hemoglobin stands tall as the definitive work on the genetics, pathophysiology, and clinical management of hemoglobinopathies and thalassemia. Drs. Steinberg, Forget, Higgs, and Nagel have gathered the world authorities on the science and clinical management of these disorders and created the authoritative textbook for researchers and clinicians alike.Authors describe the scientific basis of clinical features and provide clinicians with a clear background of disorders they treat and scientists with an essential link between their research and its clinical manifestation. Disorders of Hemoglobin is the only single-source reference on hemoglobinopathies for hematologists, pediatricians, clinical investigators, and geneticists worldwide.

Sickle Cell Disease Sickle Cell Trait

Author : Ezekiel Sandy
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"This book is based on a disease that has plagued the Cushite race from the dawn of existence: sickle cell or trait sickle cell, for which experts continue to say there is no cure. As a victim of this disease, I prayed I would be provided with the answers to overcome this serious health condition. I believed there had to be a way and was determined to find it. Inside this book is my story and the tools I discovered. Given a chance, the material within will serve as a major help for all who read. Having this disease or any other chronic illness can be a building block for learning how to overcome struggles and live your best life now. I hope this book helps you make positive changes in your health. I, Ezekiel J. Sandy, am an example of one man who overcame this illness and you can, too, if you apply the knowledge."--Author's statement from page 4 of cover.

Dying in the City of the Blues

Author : Keith Wailoo
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This groundbreaking book chronicles the history of sickle cell anemia in the United States, tracing its transformation from an "invisible" malady to a powerful, yet contested, cultural symbol of African American pain and suffering. Set in Memphis, home of one of the nation's first sickle cell clinics, Dying in the City of the Blues reveals how the recognition, treatment, social understanding, and symbolism of the disease evolved in the twentieth century, shaped by the politics of race, region, health care, and biomedicine. Using medical journals, patients' accounts, black newspapers, blues lyrics, and many other sources, Keith Wailoo follows the disease and its sufferers from the early days of obscurity before sickle cell's "discovery" by Western medicine; through its rise to clinical, scientific, and social prominence in the 1950s; to its politicization in the 1970s and 1980s. Looking forward, he considers the consequences of managed care on the politics of disease in the twenty-first century. A rich and multilayered narrative, Dying in the City of the Blues offers valuable new insight into the African American experience, the impact of race relations and ideologies on health care, and the politics of science, medicine, and disease.

The Midwives Guide to Key Medical Conditions E Book

Author : Linda Wylie
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The only book of its kind, this essential reference offers quick access to information on the effects medical conditions can have on pregnancy and childbirth. Coverage includes a brief overview of normal anatomy and physiology with concise, practical guidelines for managing disorders commonly seen in women of childbearing age. From mild diseases such as asthma to serious conditions such as heart lesions, this indispensable guide will help you manage pregnancy and childbirth in women with systemic disease, recognize the early onset of disease-related pregnancy complications, and determine when it may be necessary to refer patients to a specialist. Offers complete coverage of normal pathophysiology in both the general population and in the context of pregnancy and childbirth. Provides comprehensive midwifery management guidelines. Outlines potential consequences of disease-related complications for the fetus or neonate.